Results 21 to 30 of about 6,053 (183)

ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance

Cancer Biology & Medicine, 2020
The ATP-binding cassette transporters (ABC transporters) have been intensely studied over the past 50 years for their involvement in the multidrug resistance (MDR) phenotype, especially in cancer.
Wanjiru Muriithi, Lucy Wanjiku Macharia, Carlos Pilotto Heming, Juliana Lima Echevarria, Atunga Nyachieo, Paulo Niemeyer Filho, Vivaldo Moura Neto   +6 more
doaj   +1 more source

Ketogenic Diet and Epilepsy: What We Know So Far

Frontiers in Neuroscience, 2019
The Ketogenic Diet (KD) is a modality of treatment used since the 1920s as a treatment for intractable epilepsy. It has been proposed as a dietary treatment that would produce similar benefits to fasting, which is already recorded in the Hippocratic ...
Isabella D’Andrea Meira, Isabella D’Andrea Meira, Tayla Taynan Romão, Henrique Jannuzzelli Pires do Prado, Henrique Jannuzzelli Pires do Prado, Lia Theophilo Krüger, Maria Elisa Paiva Pires, Priscila Oliveira da Conceição   +7 more
doaj   +1 more source

Niemeyer

Crítica Marxista, 2008
Escrito como uma homenagem ao centenário do arquiteto Oscar Niemeyer, este texto procura se opor as interpretações ditas marxistas de que sua obra esta distante da realidade brasileira e que o seu sentido poético ficou aprisionado em uma modernidade apenas cabível na utopia desenvolvimentista dos anos 60.
openaire   +1 more source

The First Two Years of Instituto Estadual do Cérebro Paulo Niemeyer: Initial Results of a Brazilian Public Hospital Dedicated to Neurosurgery

Brazilian Neurosurgery, 2016
The dissemination of specialty hospitals throughout the urban centers has revolutionized the full spectrum of care for cardiology, oncology and orthopedics during the last decades.
Daniel Dutra Cavalcanti, Paulo José Pereira da Mata, Paulo Niemeyer Filho   +2 more
doaj   +1 more source

MAX NIEMEYER †. [PDF]

Beiträge zur Geschichte der deutschen Sprache und Literatur (PBB), 1912
n ...
openaire   +2 more sources

Liquid biopsy evaluation of circulating tumor DNA, miRNAs, and cytokines in meningioma patients

Frontiers in Neurology
IntroductionLiquid biopsy is a non-invasive method used to detect cancer and monitor treatment responses by analyzing blood or other bodily fluids for cancer biomarkers.
Veronica Aran, Renan Lyra Miranda, Manoela Heringer, Anna Carolina Carvalho da Fonseca, Felipe Andreiuolo, Felipe Andreiuolo, Leila Chimelli, Sylvie Devalle, Paulo Niemeyer Filho, Vivaldo Moura-Neto   +9 more
doaj   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

The genotypic and phenotypic impact of hypoxia microenvironment on glioblastoma cell lines

BMC Cancer, 2021
Background Glioblastoma is a fatal brain tumour with a poor patient survival outcome. Hypoxia has been shown to reprogram cells towards a stem cell phenotype associated with self-renewal and drug resistance properties.
Lucy Wanjiku Macharia, Wanjiru Muriithi, Carlos Pilotto Heming, Dennis Kirii Nyaga, Veronica Aran, Marianne Wanjiru Mureithi, Valeria Pereira Ferrer, Attilio Pane, Paulo Niemeyer Filho, Vivaldo Moura-Neto   +9 more
doaj   +1 more source

Lost and found in translation: the value of the human imiquimod model

British Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs, Juliette A. van den Noort, Salma Assil, Naomi B. Klarenbeek, Matthijs Moerland, Tessa Niemeyer‐van der Kolk, Robert Rissmann   +6 more
wiley   +1 more source