Results 21 to 30 of about 3,048,198 (365)
Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities [PDF]
, 2014 SIRT1, a class III histone deacetylase, plays a critical role in regulating cancer cell growth, migration and invasion, which makes it a potential target for cancer therapeutics.
Chiao, Christine Ya-Chi +6 more
core +2 more sources
A complex network perspective on clinical science [PDF]
, 2016 Contemporary classification systems for mental disorders assume that abnormal behaviors are expressions of latent disease entities. An alternative to the latent disease model is the complex network approach.
Curtiss, Joshua +2 more
core +2 more sources
Frontiers in Public Health, 2016 Introduction: Allostatic load score (ALS) summarizes the physiological effect of stress on cardiovascular, metabolic and immune systems. As immigration is stressful, ALS could be affected.Objective: Associations of age of immigration, reason for ...
Brianna A Bingham +8 more
doaj +1 more source
Effect of treatments for depression on quality of life: a meta-analysis [PDF]
, 2017 Published in final edited form as: Cogn Behav Ther. 2017 June; 46(4): 265–286. doi:10.1080/16506073.2017.1304445.Cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are the two first-line treatments for depression, but ...
Carpenter, Joseph K. +3 more
core +1 more source
Frontiers in Immunology, 2016 For more than a decade, investigators have pursued methods to genetically engineer NK cells for use in clinical therapy against cancer. Despite considerable advances in viral transduction of hematopoietic stem cells and T cells, transduction efficiencies
Mattias eCarlsten +7 more
doaj +1 more source
Synthesis of aza-rocaglates via ESIPT-mediated (3+2) photocycloaddition [PDF]
, 2016 Synthesis of aza-rocaglates, nitrogen-containing analogues of the rocaglate natural products, is reported. The route features ESIPT-mediated (3+2) photocycloaddition of 1-alkyl-2-aryl-3-hydroxyquinolinones with the dipolarophile methyl cinnamate.
Cencic, Regina +4 more
core +1 more source
Science, 2012 “When everybody gets to one side of the boat, it usually tips over.” that saying may have originated on Wall Street, but it also stands as a warning to those charting the future of U.S. biomedical research. If the United States focuses too much of its investment on one part of the research continuum, the entire enterprise may sink.
openaire +2 more sources
Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome [PDF]
, 2019 The biosynthetic capabilities of microbes underlie their growth and interactions, playing a prominent role in microbial community structure. For large, diverse microbial communities, prediction of these capabilities is limited by uncertainty about ...
Bernstein, David B. +2 more
core +1 more source
The conception of the ABCD study: From substance use to a broad NIH collaboration
Developmental Cognitive Neuroscience, 2017 Adolescence is a time of dramatic changes in brain structure and function, and the adolescent brain is highly susceptible to being altered by experiences like substance use.
N. Volkow +21 more
semanticscholar +1 more source
The NIH Human Microbiome Project.
Genome Research, 2009 The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource.
Jane L. Peterson +38 more
semanticscholar +1 more source