Results 41 to 50 of about 2,430,619 (291)
NIH Workshop on Trustworthy Data Repositories for Biomedical Sciences
, 2019 The NIH Data Science Strategic Plan aims to modernize the ecosystem of biomedical data repositories. This workshop introduced the concepts of trust principles for data repositories, which address management aspects of data repositories. The workshop also
NIH ODSS Data Science Strategic Plan Implementation Subgroup 2.1.3&2.1.6 (7301067)
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
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Scientific Reports, 2022 DNA damage is a prominent biomarker for numerous diseases, including cancer, as well as for the aging process. Detection of DNA damage routinely relies on traditional microscopy or cytometric methods.
Kelsey Gallant +6 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
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BMC Pulmonary Medicine, 2022 Objectives Lymphangioleiomyomatosis (LAM) patients with severe lung disease may be considered for lung transplantation. Clinical, physiologic, and quality of life data are usually employed for referral.
Angelo M. Taveira-DaSilva +7 more
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
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Science, 2012 “When everybody gets to one side of the boat, it usually tips over.” that saying may have originated on Wall Street, but it also stands as a warning to those charting the future of U.S. biomedical research. If the United States focuses too much of its investment on one part of the research continuum, the entire enterprise may sink.
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Harvard, NIH, and the Balance of Power in the Open Access Debate
, 2008 This article reviews the recent decision by Harvard’s Faculty of Arts & Sciences to submit scholarly articles to the University’s institutional repository prior to (or in lieu of) publication in a journal.
Medeiros, Norm
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