Results 31 to 40 of about 2,411,456 (284)
Science funding in the United States is tight, and the application process is arduous. A recent study of NIH peer-review recommends a major overhaul of the system. Will the changes prove cosmetic or curative?
openaire +2 more sources
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Complying with the NIH Public Access Policy - Copyright Considerations and Options [PDF]
On January 11, 2008, the National Institutes of Health ('NIH') adopted a revised Public Access Policy for peer-reviewed journal articles reporting research supported in whole or in part by NIH funds.
Carroll, Michael W.
core
UCAPAN UMA ABAH NIH, UMA MAMA NIH, UMA KAKAK NIH, DAN UMA SERTA PENYEBABNYA OLEH MUHAMMAD ZAINI PADA USIA 2 TAHUN 5 BULAN SAMPAI 2 TAHUN 8 BULAN (UMA ABAH NIH, UMA MAMA NIH, UMA KAKAK NIH, AND UMA UTTERANCE WITH CAUSE BY MUHAMMAD ZAINI IN THE PERIOD OF 2;5 YEARS OLD TO 2;8 YEARS OLD) [PDF]
Ucapan Uma Abah Nih, Uma Mama Nih, Uma Kakak Nih, Dan Uma Serta Penyebabnya OlehMuhammad Zaini Pada Usia 2 Tahun 5 Bulan Sampai 2 Tahun 8 Bulan. Penelitian ini bertujuanuntuk mendeskripsikan dan menjelaskan tentang ucapan uma abah nih, uma mama nih, uma ...
M. Rafiek, M. Rafiek
core +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The NIH Public Access Policy [PDF]
A how-to guide on complying the with NIH Public Access ...
Farris, R. Nicholas
core
The biological characterization of an individual patient's tumor by noninvasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known.
Cynthia Ménard +18 more
doaj +1 more source
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source

