Results 31 to 40 of about 2,411,456 (284)

A metareview at the NIH [PDF]

open access: yesNature Medicine, 2008
Science funding in the United States is tight, and the application process is arduous. A recent study of NIH peer-review recommends a major overhaul of the system. Will the changes prove cosmetic or curative?
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Complying with the NIH Public Access Policy - Copyright Considerations and Options [PDF]

open access: yes, 2008
On January 11, 2008, the National Institutes of Health ('NIH') adopted a revised Public Access Policy for peer-reviewed journal articles reporting research supported in whole or in part by NIH funds.
Carroll, Michael W.
core  

UCAPAN UMA ABAH NIH, UMA MAMA NIH, UMA KAKAK NIH, DAN UMA SERTA PENYEBABNYA OLEH MUHAMMAD ZAINI PADA USIA 2 TAHUN 5 BULAN SAMPAI 2 TAHUN 8 BULAN (UMA ABAH NIH, UMA MAMA NIH, UMA KAKAK NIH, AND UMA UTTERANCE WITH CAUSE BY MUHAMMAD ZAINI IN THE PERIOD OF 2;5 YEARS OLD TO 2;8 YEARS OLD) [PDF]

open access: yes, 2017
Ucapan Uma Abah Nih, Uma Mama Nih, Uma Kakak Nih, Dan Uma Serta Penyebabnya OlehMuhammad Zaini Pada Usia 2 Tahun 5 Bulan Sampai 2 Tahun 8 Bulan. Penelitian ini bertujuanuntuk mendeskripsikan dan menjelaskan tentang ucapan uma abah nih, uma mama nih, uma ...
M. Rafiek, M. Rafiek
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

The NIH Public Access Policy [PDF]

open access: yes, 2012
A how-to guide on complying the with NIH Public Access ...
Farris, R. Nicholas
core  

An Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast Enhancement

open access: yesMolecular Imaging, 2005
The biological characterization of an individual patient's tumor by noninvasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known.
Cynthia Ménard   +18 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

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