Results 51 to 60 of about 2,430,619 (291)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

UCAPAN UMA ABAH NIH, UMA MAMA NIH, UMA KAKAK NIH, DAN UMA SERTA PENYEBABNYA OLEH MUHAMMAD ZAINI PADA USIA 2 TAHUN 5 BULAN SAMPAI 2 TAHUN 8 BULAN (UMA ABAH NIH, UMA MAMA NIH, UMA KAKAK NIH, AND UMA UTTERANCE WITH CAUSE BY MUHAMMAD ZAINI IN THE PERIOD OF 2;5 YEARS OLD TO 2;8 YEARS OLD)

, 2017
Ucapan Uma Abah Nih, Uma Mama Nih, Uma Kakak Nih, Dan Uma Serta Penyebabnya OlehMuhammad Zaini Pada Usia 2 Tahun 5 Bulan Sampai 2 Tahun 8 Bulan. Penelitian ini bertujuanuntuk mendeskripsikan dan menjelaskan tentang ucapan uma abah nih, uma mama nih, uma ...
M. Rafiek, M. Rafiek
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

NIH RDD 2023

, 2023
Poster and materials for NIH Rare Disease Day ...
Ida Hakkarinen
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Novel Pathogenic Variant in IL2RG Affecting the Signal Peptide Results in mRNA Instability, Decreased IL2RG Expression, and Atypical Late-Onset Immunodeficiency

Journal of Human Immunity
X-linked severe combined immunodeficiency (SCID-X1) presents as T-B+NK- SCID, due to mutations in the common γ chain (IL2RG/CD132), a shared component of several cytokine receptors.
Muslima Hussain, Nisha Nagarsheth, Julia Jones, Irene Cortese, Corina Gonzalez, Suk See De Ravin, Xiaolin Wu, Michelle Ma, Hyesun Kuehn, Sergio Rosenzweig, Alan Hoofring, Hannah Ambrose, Matthew Drew, Dominic Esposito, Sung-Yun Pai   +14 more
doaj   +1 more source

Key Role of alpha-Toxin in Fatal Pneumonia Caused by Staphylococcus aureus Sequence Type 398

, 2016
Intramural NIH HHSNIAID NIH HHSNIH, Bethesda, MD 20892 USAUniv Estadual Paulista, Botucatu, SP, BrazilUniv Estadual Paulista, Botucatu, SP, BrazilNIAID NIH HHS: ZIA ...
Bonesso, Mariana F. [UNESP], Otto, Michael, Yeh, Anthony J., Cunha, Maria L. R. S. [UNESP], McCausland, Joshua, Sobrinho, Moises T. [UNESP], Ronchi, Carlos F. [UNESP], Villaruz, Amer E., Cheung, Gordon Y. C., Joo, Hwang-Soo, Fortaleza, Carlos M. C. B. [UNESP], Cavalcante, Ricardo S. [UNESP]   +11 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

478 Rigor and reproducibility activities across the CTSA consortium: A retrospective review of accomplishments

Journal of Clinical and Translational Science
Objectives/Goals: To assess how rigor and reproducibility activities across the Clinical and Translational Science Awards (CTSA) consortium are aligned with NCATS Translational Science Principles (TSPs) and the NIH’s new plan to promote gold standard ...
Francisco Leyva, Gallya Gannot, Monica Donerson, Andrew Vaught, Katherine Patel, Soju Chang   +5 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source