Results 61 to 70 of about 2,411,456 (284)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Novel Pathogenic Variant in IL2RG Affecting the Signal Peptide Results in mRNA Instability, Decreased IL2RG Expression, and Atypical Late-Onset Immunodeficiency

Journal of Human Immunity
X-linked severe combined immunodeficiency (SCID-X1) presents as T-B+NK- SCID, due to mutations in the common γ chain (IL2RG/CD132), a shared component of several cytokine receptors.
Muslima Hussain, Nisha Nagarsheth, Julia Jones, Irene Cortese, Corina Gonzalez, Suk See De Ravin, Xiaolin Wu, Michelle Ma, Hyesun Kuehn, Sergio Rosenzweig, Alan Hoofring, Hannah Ambrose, Matthew Drew, Dominic Esposito, Sung-Yun Pai   +14 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

GREI Collaborative Webinar Series on Data Sharing in Generalist Repositories

, 2022
GREI Collaborative Webinar Series on Data Sharing in Generalist Repositories Access resources from a series of presentations and panel discussions by generalist repositories to learn about available repository resources and best practices for sharing ...
Amanda Staller, Van Gulick, Ana, Nicole Pfeiffer, Staller, Amanda, Ana Van Gulick, Pfeiffer, Nicole   +5 more
core   +1 more source

NIH data overhaul

Today we release a major overhaul of our NIH grants data that includes some big improvements to how we track and display disruptions to NIH funding.
Eric Scott
core   +2 more sources

P469: Clinical relevance of mosaic variants detected from exome sequencing data

Genetics in Medicine Open, 2023
Rajarshi Ghosh, Andrew Oler, Mark Rustad, Samuel Li, Jia Yan, Morgan Similuk, Steven Holland, Magdalena Walkiewicz-Yvon   +7 more
doaj   +1 more source

A Biallelic HELIOS Nonsense Mutation Disrupting Dimerization Is Associated with a Novel Syndromic Immunodeficiency

Journal of Human Immunity
HELIOS is an IKAROS-family zinc-finger transcription factor that plays an important role in regulatory T cell function and conventional T cell homoeostasis.
Hye Sun Kuehn, Azzeddine Tahiat, Ana Esteve-Sole, Jennifer Stoddard, Julie Niemela, Agustin Gil Silva, Marita Bosticardo, Ottavia Delmonte, Luigi Notarangelo, Sergio Rosenzweig   +9 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source