Results 81 to 90 of about 2,411,456 (284)

A Direction for the Next Decade of NIH-Funded Health Literacy Research

Health Literacy Research and Practice, 2020
Elaine C. Khoong, Dean Schillinger
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Edward A. Adelberg to Director of National Cancer Institute of Health of the NIH

, 1986
Letter to the Director of the National Cancer Institute at the NIH explaining Trinkaus's laboratory space once he becomes emeritus.Typed letter1 ...
Adelberg, Edward A.
core  

Insulin and IGF-1 induce different patterns of gene expression in mouse fibroblast NIH-3T3 cells: Identification by cDNA microarray analysis

, 2001
International audienceThe IGF-1 receptor and the related insulin receptor are similar in structure and activate many of the same postreceptor signaling pathways, yet they mediate distinct biological functions.
Dupont, Joëlle, Khan, Javed, Helman, Lee, Leroith, Derek, Qu, Bao-He, Metzler, Paul   +5 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

UCAPAN UMA ABAH NIH, UMA MAMA NIH, UMA KAKAK NIH, DAN UMA SERTA PENYEBABNYA OLEH MUHAMMAD ZAINI PADA USIA 2 TAHUN 5 BULAN SAMPAI 2 TAHUN 8 BULAN (UMA ABAH NIH, UMA MAMA NIH, UMA KAKAK NIH, AND UMA UTTERANCE WITH CAUSE BY MUHAMMAD ZAINI IN THE PERIOD OF 2;5 YEARS OLD TO 2;8 YEARS OLD)

, 2020
Uma Abah Nih, Uma Mama Nih, Uma Kakak Nih, And Uma Utterance With Cause By Muhammad Zaini In The Period Of 2;5 Years Old To 2;8 Years Old. This study aimed to describe and explain the direction uma abah nih, uma mama nih, uma kakak nih, and uma and the ...
Muhammad, Rafiek
core  

P475: Minimizing false negatives in NGS-based diagnostic testing by optimizing variant filtering strategy*

Genetics in Medicine Open, 2023
Bin Guan, Amelia Naik, Ehsan Ullah, David McGaughey, Aime Agather, Brian Brooks, Robert Hufnagel   +6 more
doaj   +1 more source

LLM research on public biosignals data is needed to protect patients

npj Digital Medicine
Large language models (LLMs) have expanded the capabilities of AI and created new opportunities in medicine. To promote the development of safe and innovative digital health tools, there must be public biosignals datasets that encourage research and ...
James Anibal, Jasmine Gunkel, Hannah Huth, Bradford J. Wood   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source