Results 71 to 80 of about 2,430,619 (291)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

O30: Graphics and filters make it easier to evaluate many variants in ClinVar search results*

Genetics in Medicine Open, 2023
Melissa Landrum, Shanmuga Chitipiralla, Kuljeet Kaur, Douglas Hoffman, Vitaly Lyoshin, Zenith Maddipatla, David Shao, Guangfeng Song, George Zhou, Andrew Russette, Brandi Kattman   +10 more
doaj   +1 more source

A Biallelic HELIOS Nonsense Mutation Disrupting Dimerization Is Associated with a Novel Syndromic Immunodeficiency

Journal of Human Immunity
HELIOS is an IKAROS-family zinc-finger transcription factor that plays an important role in regulatory T cell function and conventional T cell homoeostasis.
Hye Sun Kuehn, Azzeddine Tahiat, Ana Esteve-Sole, Jennifer Stoddard, Julie Niemela, Agustin Gil Silva, Marita Bosticardo, Ottavia Delmonte, Luigi Notarangelo, Sergio Rosenzweig   +9 more
doaj   +1 more source

NiH-Catalyzed Proximal-Selective Hydroamination of Unactivated Alkenes with Anthranils

The regioselective hydroamination of unactivated alkenes is a long-standing challenge in organic synthesis. Herein, we report a NiH-catalyzed proximal-selective hydroamination of unactivated alkenes with 8-aminoquinoline (AQ) as a bidentate auxiliary and
Yinglin Luo (13944394), Wanxuan Zhao (13944391), Yushan Cui (10486672), Yanping Huo (545287), Xiao-Qiang Hu (1528684), Haiyi Xie (12258164), Yang Gao (18005)   +6 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Probit Estimates of NIH R01 Award by degree and NIH funding rank.

, 2018
Probit Estimates of NIH R01 Award by degree and NIH funding rank.
Raynard Kington (12880), Walter T. Schaffer (5963276), Unni Jensen (2872262), Joshua Schnell (5963273), Jodi Basner (5963270), Donna K. Ginther (796044)   +5 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Edward A. Adelberg to Director of National Cancer Institute of Health of the NIH

, 1986
Letter to the Director of the National Cancer Institute at the NIH explaining Trinkaus's laboratory space once he becomes emeritus.Typed letter1 ...
Adelberg, Edward A.
core  

NIH Category Schema

, 2019
NIH category ...
Team Figshare (5230615)
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source