Results 81 to 90 of about 3,048,198 (365)

Total synthesis of aurofusarin: studies on the atropisomeric stability of bis-naphthoquinones [PDF]

, 2018
An efficient annulation involving pyrone addition to a quinone and Dieckmann condensation was developed for rapid assembly of a γ-naphthopyrone monomeric precursor to the bis-naphthoquinone natural product aurofusarin.
Allen, Ashley, Bao, Berkessel, Birchall, Bringmann, Bringmann, Chen, Corey, Crimmins, Dao, Donner, Dwyer, Flegel, Frandsen, Gao, Gray, Helder, Jew, Konkol, Lee, Leeper, Liau, Masson, Morishita, Natori, Romaine, Shi, Shibata, Shibata, Shibata, Shirakawa, Shirakawa, Sperry, Sun, Takeya, Takizawa, Varun, Wu, Yeung, Zeeck, Zhang, Ōki   +42 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Identifying the protein folding nucleus using molecular dynamics [PDF]

, 2000
Molecular dynamics simulations of folding in an off-lattice protein model reveal a nucleation scenario, in which a few well-defined contacts are formed with high probability in the transition state ensemble of conformations.
Buldyrev, Sergey V., Dokholyan, Nikolay V., Shakhnovich, Eugene I., Stanley, Harry E.   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Handgrip Strength: A Comparison of Values Obtained From the NHANES and NIH Toolbox Studies

American Journal of Occupational Therapy, 2019
Importance: Handgrip dynamometry is probably the most commonly used method to characterize overall human muscle strength. Objective: To compare and summarize grip strength measurements obtained from two population-based studies.
Richard W. Bohannon, Ying-Chih Wang, S. Yen, K. Grogan   +3 more
semanticscholar   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A COUPLED-CHANNELS POTENTIAL FIT DESCRIBING THE LOW-LYING X²∆, ²Π AND ²Σ⁺ STATES OF NiH TO EXPERIMENTAL ACCURACY [PDF]

, 2021
I. Havalyova, P. Crozet, Amanda Ross, A. Pashov, I Bozhinova   +4 more
openalex   +1 more source

Benefits and challenges with diagnosing chronic and late acute GvHD in children using the NIH consensus criteria.

Blood, 2019
Chronic graft-versus-host disease (cGvHD) and late-acute GvHD (L-aGvHD) are understudied complications of allogeneic hematopoietic stem cell transplantation in children.
G. Cuvelier, Eneida R. Nemecek, J. Wahlstrom, C. Kitko, V. Lewis, T. Schechter, D. Jacobsohn, Andrew C. Harris, M. Pulsipher, H. Bittencourt, S. Choi, Emi H. Caywood, K. Kasow, M. Bhatia, B. Oshrine, A. Flower, S. Chaudhury, D. Coulter, J. Chewning, M. Joyce, S. Savaşan, A. Pawlowska, G. Megason, D. Mitchell, A. Cheerva, A. Lawitschka, L. West, Bo Pan, Yazid N Alhamarneh, A. Halevy, K. Schultz   +30 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

METTL13 methylation of eEF1A increases translational output to promote tumorigenesis [PDF]

, 2019
Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to ...
Bassik, Michael Cory, Caporicci, Marcello, Carlson, Scott Moore, Elias, Joshua Eric, Francis, Joel William, Fuentes, Mary Esmeralda, Gozani, Or, Hausmann, Simone, Hulea, Laura, Kim, Michael Paul, Li, Ami, Liu, Shuo, Lofgren, Shane Michael, Lu, Jiuwei, Maitra, Anirban, Mazur, Pawel Karol, Nicholas, Dang Nguyen, Pillai, Renjitha, Porco, John Anthony, Song, Jikui, Tandoc, Kristofferson, Topisirovic, Ivan, Van Rechem, Capucine, Wang, Huamin, Wistuba, Ignacio Ivan   +24 more
core   +1 more source