The mechanisms of Pin1 as targets for cancer therapy. [PDF]
Front ImmunolTargeted therapy has considerable promise for the effective eradication of cancer at the primary tumor site prior to subsequent metastasis. Using this therapeutic approach, gaining an understanding of mechanistic cancer models is essential for ...
Liu C, Dan L, Li Q, Bajinka O, Yuan X.
europepmc +3 more sources
MicroRNA-296-5p is differentially expressed in individuals with and without HIV-1 infection [PDF]
Genetics and Molecular Biology, 2020 MicroRNAs are considered as potential biomarkers, agents, or therapeutic targets; few studies have addressed the expression of miRNAs in treatment-naïve patients infected with HIV-1.
Jhonathan Cárdenas-Bedoya +7 more
doaj +1 more source
Acta Cirúrgica Brasileira, 2022 Purpose: To investigate the role of peptidyl-prolyl cis/trans isomerase 1 (Pin1) on renal ischemia-reperfusion (I/R) injury and underlying mechanism. Methods: By establishing the in vitro and in vivo models of renal I/R, the role of Pin1 was explored by
Honglin Yu +3 more
doaj +1 more source
Single nucleotide polymorphisms of PIN1 promoter region and cancer risk: evidence from a meta-analysis. [PDF]
PLoS ONE, 2013 Peptidylprolyl cis/trans isomerase NIMA-interacting 1 (PIN1) is involved in the process of tumorigenesis. The two single nucleotide polymorphisms (-677T>C, -842G>C) in the PIN1 promoter region have been suspected of being associated with cancer risk for ...
Jing-Jing Peng +7 more
doaj +1 more source
Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2021.2 [PDF]
, 2021 Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins.
Annett, Stephanie, Robson, Tracy
core +2 more sources
Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2023.1 [PDF]
, 2023 Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins.
Annett, Stephanie, Robson, Tracy
core +2 more sources
Small interfering RNAs in tendon homeostasis. [PDF]
, 2021 Background: Tenogenesis and tendon homeostasis are guided by genes encoding for the structural molecules of tendon fibres. Small interfering RNAs (siRNAs), acting on gene regulation, can therefore participate in the process of tendon healing.Sources of ...
Gargano, Giuseppe +3 more
core +1 more source
A conserved set of maternal genes? Insights from a molluscan transcriptome [PDF]
, 2014 The early animal embryo is entirely reliant on maternal gene products for a ‘jump-start’ that transforms a transcriptionally inactive embryo into a fully functioning zygote.
Blaxter, Mark L. +4 more
core +4 more sources
Proteomic Profiling of Hematopoietic Stem/Progenitor Cells after a Whole Body Exposure of CBA/CaJ Mice to Titanium (48Ti) Ions [PDF]
, 2015 Myeloid leukemia (ML) is one of the major health concerns from exposure to radiation. However, the risk assessment for developing ML after exposure to space radiation remains uncertain.
Gordon, Chris +6 more
core +2 more sources
Genome-wide identification of CBX2 targets: insights in the human sex development network [PDF]
, 2015 CBX2 (Chromobox homolog 2) is a chromatin modifier that plays an important role in sexual development and its disorders (disorders of sex development, DSD), yet the exact rank and function of human CBX2 in this pathway remains unclear. Here, we performed
Biason-Lauber, Anna +2 more
core +1 more source