Results 61 to 70 of about 13,526 (188)

Contemporary Fibrotic Interstitial Lung Disease Outcomes: A Multicentre National Cohort Study

Respirology, EarlyView.
This study determined contemporary transplant‐free survival in fibrotic interstitial lung disease (ILD), identified baseline factors associated with death or transplant, and assessed performance of the ILD‐GAP (Gender, Age, Physiology) index in a contemporary cohort.
Tyler Pitre, Christopher J. Ryerson, Shaun Ong, Kerri A. Johannson, Deborah Assayag, Veronica Marcoux, Martin Kolb, Helene Manganas, Daniel‐Costin Marinescu, Jolene H. Fisher   +9 more
wiley   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Nintedanib for systemic sclerosis-associated interstitial lung disease [PDF]

, 2019
BACKGROUND: Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis and a leading cause of systemic sclerosis-related death. Nintedanib, a tyrosine kinase inhibitor, has been shown to have antifibrotic and antiinflammatory effects
Mayes, Maureen D, Smith, Vanessa, Maher, Toby M, Fischer, Aryeh, Stowasser, Susanne, Azuma, Arata, SENSCIS Trial Investigators, Mayes, Maureen D; https://orcid.org/, Maher, Toby M., Maher, Toby TM, Highland, Kristin B, Distler, Oliver; https://orcid.org/, Girard, Mannaig, Houssiau, Frédéric, Distler, Oliver, Tetzlaff, Kay, Gahlemann, Martina, Kuwana, Masataka; https://orcid.org/, Mayes, Maureen D., Raghu, Ganesh, Sauter, Wiebke, Kuwana, Masataka, Alves, Margarida, SENSCIS Trial Investigator, for the, SENSCIS Trial Investigators, Benjamin Bondue, Highland, Kristin B., Clerisme-Beaty, Emmanuelle, Bondue, Benjamin, Mayes, Maureen MD   +28 more
core   +1 more source

Honokiol regulates Acute respiratory distress syndrome (ARDS)‐associated pulmonary fibrosis via the miR‐19a‐3p/POSTN axis

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Acute respiratory distress syndrome (ARDS) and subsequent pulmonary fibrosis are associated with high mortality and limited treatment options. Periostin (POSTN) is a profibrotic mediator predicted to be regulated by microRNA‐19a‐3p (miR‐19a‐3p), but the relevance of this axis in ARDS‐associated pulmonary fibrosis remains
Weilun Liu, Hsiaohsuan Wang, Hsuanfu Kuo, Chiahung Yen, Modasang Hua, Chiayuan Chang, Zhiwei Xu, Ifan Liu, Chongchao Hsieh, Chihhsin Hsu, Chiayang Li, Shuchi Wang, Yunghsiang Chen, Menghsuan Cheng, Polen Liu   +14 more
wiley   +1 more source

Effects of Nintedanib on the Lungs via NLRP3 in a Model of Lipopolysaccharide-induced Acute Lung Injury in Rats

Aim: To demonstrate the possible protective efficacy of nintedanib, a tyrosine kinase inhibitor with demonstrated antifibrotic and antitumor activity, in a model of acute lung injury (ALI), a severe lung disease, through NLR family pyrin domain ...
ÇADIRCI, Elif, Zekai HALICI, HALICI, Zekai, Elif ÇADIRCI, Erdem TOKTAY, Pelin AYDIN, Tanriverdiyeva, Gulchin, Gulchin TANRİVERDİYEVA, Aydin, Pelin, TOKTAY, Erdem   +9 more
core   +1 more source

Supplementary Material for: Insights from the German Compassionate Use Program of Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis

, 2016
Background: Nintedanib is approved for the treatment of idiopathic pulmonary fibrosis (IPF) and has been shown to slow disease progression by reducing annual lung function decline.
Müller-Quernheim J. (3032973), Milger K. (3032955), Kohlhaeufl M.J. (3032976), Kreuter M. (3032970), Bonella F. (3032964), Neurohr C. (3032979), German Nintedanib Compassionate Use Consortium (3032952), Keller C. (3032961), Prasse A. (3032967), Hagmeyer L. (3032958)   +9 more
core   +1 more source

MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis

Cancer Science, EarlyView.
MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei, Xiangyu Liu, Shimin Hu, Xiaodie Shen, Yingli Liu, Xinxin Qin, Ye Zhou, Jianqi Zheng, Bingke Tian, Jingfang Hong, Yongxia Song, Di Wang, Linlin Peng, Jinxia Ding, Fang Wang, Hui Zhang, Shihao Zhang, Huan Qiu   +17 more
wiley   +1 more source

Assessing the impact of nintedanib and pirfenidone on lung function in idiopathic pulmonary fibrosis: A comprehensive meta-analysis [PDF]

Vojnosanitetski Pregled
Background/Aim. The incidence of idiopathic pulmonary fibrosis (IPF) has been increasing each year. Although pirfenidone and nintedanib were approved in 2014, they received only conditional recommendations, and no medication has yet been strongly ...
Luan Zhaoji, Muthal Amol, Sadar Smeeta
doaj   +1 more source

Clinical potential of nintedanib for the second-line treatment of advanced non-small-cell lung cancer: current evidence [PDF]

, 2014
Sacha I Rothschild Department of Internal Medicine, Medical Oncology, University Hospital Basel, Basel, Switzerland Abstract: The therapeutic landscape in non-small-cell lung cancer (NSCLC) is changing.
Rothschild SI
core  

Human Embryonic Stem Cell‐Derived Immunity‐And‐Matrix‐Regulatory Cells Attenuate Pulmonary Fibrosis via MMP1‐Mediated Collagen Degradation

Cell Proliferation, EarlyView.
Human embryonic stem cell‐derived Immunity‐and‐Matrix‐Regulatory Cells (IMRCs) effectively attenuate pulmonary fibrosis by secreting Matrix Metalloproteinase‐1 (MMP1), which directly degrades excess collagen I in the extracellular matrix. By directly degrading collagen I, IMRCs reverse ECM stiffness, suppress myofibroblast activation, and promote a ...
Zhongwen Li, Dingyun Song, Faguo Sun, Licheng Song, Bin An, Tingting Gao, Jingjing Liu, Kan Zhang, Kaidi Liu, Kaiwei Wu, Yajing Li, Yi Yang, Yaru Liu, Ruofan Su, Zai Wang, Tiemei Zhao, Huaiyong Chen, Li Xiao, Liang Peng, Liu Wang, Wei Li, Lixin Xie, Jie Hao, Huaping Dai, Jun Wu   +24 more
wiley   +1 more source