Results 51 to 60 of about 13,526 (188)

The effect of nintedanib on lung functions and survival in idiopathic pulmonary fibrosis: real-life analysis of the Czech EMPIRE registry

BMC Pulmonary Medicine, 2023
Introduction The antifibrotic drug nintedanib is used for the treatment of idiopathic pulmonary fibrosis (IPF). We analysed the effect of nintedanib on antifibrotic treatment outcome in real-world cohorts of Czech EMPIRE registry.
Marianna Štefániková, Martina Doubková, Petra Ovesná, Martina Šterclová, Ladislav Lacina, Monika Žurková, Martina Plačková, Vladimír Bartoš, Ivana Janíčková, Radka Bittenglová, Jan Anton, Ľubica Sýkorová, Vladimíra Lošťáková, Pavlína Musilová, Hana Šuldová, Radka Mokošová, Jurij Didyk, Lenka Šišáková, Pavlína Lisá, Jaroslav Lněnička, Hana Dařičková, Daniel Doležel, Jana Pšikalová, Richard Tyl, Renata Králová, Martina Koziar Vašáková   +25 more
doaj   +1 more source

Nintedanib inhibits tumor lymphangiogenesis.

, 2016
(A,B) Representative images of LYVE-1-stained sections of H1993 tumors from vehicle and nintedanib treated mice. (C) The density of lymphatic vessels in H1993 xenografts is significantly lower in nintedanib treated mice (5.254 ± 2.745, n = 5) than in ...
John D. Minna (158214), Robert C. Sibley (3182082), Michael T. Dellinger (337877), Erin Regan (3182085), Asitha Silva (3182088), Bercin Kutluk Cenik (3182079), Luc Girard (67129)   +6 more
core   +1 more source

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Andrographolide Modulates Fibrogenic and Oxidative Stress Responses in Human Lung Fibroblasts

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pulmonary fibrosis is a progressive lung disorder characterized by fibroblast activation and excessive extracellular matrix deposition. Andrographolide (ANDRO) has been reported to attenuate pulmonary fibrosis, but the underlying molecular mechanisms remain incompletely understood.
Yu‐Hsin Tseng, Yen‐Hsien Wu, Yi‐Ching Liu, I‐Chen Chen, Chung‐Yu Yeh, Shang‐En Huang, Ren‐Long Jan, Jwu‐Lai Yeh, Jong‐Hau Hsu   +8 more
wiley   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Pregnancy in CTD‐interstitial lung disease: Current evidence, clinical challenges, and a proposed management algorithm

Rheumatology &Autoimmunity, EarlyView.
Summary of pregnancy management in CTD‐ILD across preconception, antenatal, and postpartum phases, emphasizing risk stratification and multidisciplinary care. 6MWT, 6‐min walk test; CTD‐ILD: connective tissue disease‐interstitial lung disease; DLCO, diffusion capacity of the lung for carbon monoxide; FVC, forced vital capacity; MDT, multidisciplinary ...
Khaled Aldhuaina, Ghaydaa Aldabie, Mohammad Abdulsalam, Ali Jawad   +3 more
wiley   +1 more source

No relevant pharmacokinetic drug-drug interaction between nintedanib and pirfenidone [PDF]

, 2018
Nintedanib and pirfenidone are approved treatments for idiopathic pulmonary fibrosis (IPF). This open-label, two-group trial investigated the pharmacokinetic drug-drug interaction between these two drugs in patients with IPF.Subjects not treated with ...
Fletcher, Sophie, Maher, Toby M, Stowasser, Susanne, Adamali, H, Chaudhuri, Nazia, Wiebe, S, Fletcher, S, Schlenker-Herceg, R, Maher, TM, Wind, S, Baker, A, Wiebe, Sabrina, Hohl, Kathrin, Richeldi, L, Chaudhuri, N, Richeldi L., Hohl, K, Stowasser, S, Adamali, Huzaifa, Schlenker-Herceg, Rozsa, Baker, Andrew, Richeldi, Luca, Wind, Sven   +22 more
core   +2 more sources

Gender-age-physiology stage and body mass index are useful predictors of nintedanib discontinuation and prognosis in patients with idiopathic pulmonary fibrosis and progressive fibrotic interstitial lung diseases

BMC Pulmonary Medicine
Introduction Data on risk factors for discontinuation of nintedanib in patients with interstitial lung diseases (ILDs) are limited. The differences in tolerability between patients with idiopathic pulmonary fibrosis (IPF) and those with progressive ...
Kai Yazaki, Masashi Matsuyama, Hiroaki Satoh, Kunihiko Miyazaki, Naoki Arai, Yukio Ishii, Takeo Endo, Takayuki Kaburagi, Takeshi Kawakami, Hiroaki Iijima, Toshiaki Motegi, Shigen Hayashi, Norihiro Kikuchi, Tohru Sakamoto, Nobuyuki Hizawa   +14 more
doaj   +1 more source

Safety and survival data in patients with idiopathic pulmonary fibrosis treated with nintedanib: pooled data from six clinical trials

BMJ Open Respiratory Research, 2019
Introduction Nintedanib slows disease progression in patients with idiopathic pulmonary fibrosis (IPF) by reducing the rate of decline in forced vital capacity, with an adverse event profile that is manageable for most patients.
Paul Hernandez, Susanne Stowasser, Daniel Wachtlin, Bruno Crestani, Lisa Lancaster, Yoshikazu Inoue, Lazaro Loaiza, Manuel Quaresma, Luca Richeldi   +8 more
doaj   +1 more source

CT‐Based Biomarkers for Predicting Progressive Phenotypes in Interstitial Lung Diseases: A Retrospective Cohort Study

Respirology, EarlyView.
This study demonstrates that the Single Time Point Prediction score, a novel machine learning–based imaging biomarker, along with established quantitative CT measures, is significantly associated with disease progression in non‐IPF ILD. This imaging metric may enable earlier identification of high‐risk patients and support personalised treatment ...
Ju Hyun Oh, Jin Woo Song, Jonathan Goldin, S. Samuel Weigt, Augustine Chung, Jared D. Wilkinson, Fereidoun Abtin, Lila Pourzand, Bianca Villegas, Jihey Lee, Kyungjong Lee, Grace Hyun J. Kim   +11 more
wiley   +1 more source