Results 41 to 50 of about 3,638 (166)

Hemolytic Disease of the Fetus and Newborn: Fetal RHD Genotyping, Targeted Prophylaxis, and Prenatal Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in prenatal care primarily caused by maternal alloimmunization against fetal red blood cell antigens, most commonly the D antigen. Noninvasive fetal RHD genotyping, used as a screening tool, enables targeted antenatal prophylaxis and has been implemented in several
Emilie Thorup, Steffen Thorsen, Morten Hanefeld Dziegiel, Olav Bjørn Petersen, Frederik Banch Clausen   +4 more
wiley   +1 more source

Clinical Utility of Nuchal Translucency Measurement in First‐Trimester Ultrasound Screening in a Setting With First‐Tier NIPT for Aneuploidy Screening

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To investigate the additional clinical value of nuchal translucency (NT) measurement at the first‐trimester anomaly scan (FTAS) in a setting with first‐tier non‐invasive prenatal testing (NIPT). Method This nationwide prospective cohort study, part of the IMITAS study on FTAS implementation, included all pregnancies with increased NT
Eline E. R. Lust, Kim Bronsgeest, Lidewij Henneman, Neeltje M. T. H. Crombag, Caterina M. Bilardo, Robert‐Jan H. Galjaard, Esther Sikkel, Audrey B. C. Coumans, Ayten Elvan‐Taşpınar, Sander Galjaard, Attie T. J. I. Go, Gwendolyn T. R. Manten, Eva Pajkrt, Elisabeth van Leeuwen, Monique C. Haak, Mireille N. Bekker   +15 more
wiley   +1 more source

A Method to Create NIPT Samples with Turner Disorder to Evaluate NIPT Algorithms

VNU Journal of Science: Computer Science and Communication Engineering, 2023
Noninvasive prenatal test (NIPT) is a widely used screening method to detect numerical aberrations on autosomal chromosomes with high sensitivity and specificity.  However, predicting abnormalities on sex chromosomes is much more challenging due to complicated genomic characteristics of sex chromosomes.
openaire   +1 more source

Incidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases

Clinical Case Reports, 2022
We present a clinical case where a complex abnormal non‐invasive prenatal test (NIPT) result in a research project revealed carcinoma of the breast in the pregnant woman.
Maria Hammer Moellgaard, Ida Charlotte Bay Lund, Naja Becher, Anne‐Bine Skytte, Lotte Andreasen, Malgorzata Ilona Srebniak, Ida Vogel   +6 more
doaj   +1 more source

Development and performance evaluation of an artificial intelligence algorithm using cell-free DNA fragment distance for non-invasive prenatal testing (aiD-NIPT)

Frontiers in Genetics, 2022
With advances in next-generation sequencing technology, non-invasive prenatal testing (NIPT) has been widely implemented to detect fetal aneuploidies, including trisomy 21, 18, and 13 (T21, T18, and T13).
Junnam Lee, Junnam Lee, Sae-Mi Lee, Jin Mo Ahn, Tae-Rim Lee, Wan Kim, Eun-Hae Cho, Chang-Seok Ki   +7 more
doaj   +1 more source

Diagnosed After Birth—But Detectable Before? A Cohort Study of Prenatal Testing Potential

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To evaluate the yield of prenatal genetic testing in infants with a confirmed genetic diagnosis. Methods We retrospectively reviewed records of infants with a genetic diagnosis who were evaluated using a standardized genetic consult and testing approach. The predicted yield of various prenatal genetic sceening and diagnostic tools in
Allison Schartman, Olivia Woods, Leah Wetherill, Amy M. Breman, Benjamin M. Helm, Kristen Suhrie, Kristyne Stone   +6 more
wiley   +1 more source

Attitudes Toward Prenatal Interventions in the Fanconi Anemia Community

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective In‐utero cell and gene therapies may offer prenatal treatment options for inherited diseases. Preclinical data suggests in‐utero (IU) hematopoietic stem cell transplantation (HSCT) could prevent Fanconi anemia (FA) related bone marrow failure without genotoxic conditioning or immune suppression.
Tony Lum, Catherine Lee, Tippi MacKenzie, Billie Lianoglou, Agnieszka Czechowicz   +4 more
wiley   +1 more source

Study on High Activity and Outstanding Stability of Hollow-NiPt@SiO2 Core–Shell Structure Catalyst for DRM Reaction

Frontiers in Chemistry, 2020
A neoteric hollow-NiPt@SiO2 core–shell structure catalyst with 7-nm-sized hollow NiPt alloy nanoparticle (NP) packaged by SiO2 shell was prepared by a classic Stober method.
Guangying Wang, Yan Liang, Jian Song, Hui Li, Yu Zhao   +4 more
doaj   +1 more source

“The Way We Do Things is Unsustainable”—Exploring Symptoms of Burnout Among Healthcare Professionals in Prenatal Genomics

Prenatal Diagnosis, EarlyView.
ABSTRACT Objectives This research explored a cross‐country comparison of qualitative and quantitative data assessing the experiences of prenatal genomic healthcare professionals (HCP) in Australia and the Netherlands. Method The interview script included open‐ended questions on work experience, validated scales on compassion fatigue and stress, and ...
Maayke de Koning, Sarah Long, Marit de Vries, Holly Evans, Lauren Kelada, Monique Haak, Gemma Fernihough, Gijs Santen, Manon Suerink, Tony Roscioli   +9 more
wiley   +1 more source

Correlation of Core Muscle Strength and Lung Capacity among College-going Students: A Cross-sectional Observational Study

Journal of Clinical and Diagnostic Research
Introduction: The abdominal muscles play a crucial role in posture, trunk stability, and respiration. They regulate Intra-abdominal Pressure (IAP), support spinal stability, and function as accessory respiratory muscles during increased respiratory ...
M Chinmayi, SN Tejaswini, Abeeshna Ashok
doaj   +1 more source