Results 71 to 80 of about 642,149 (371)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Is nitrate a good biomarker of the nitric oxide status? / Este ionul nitrat un bun biomarker al producţiei endogene de monoxid de azot?

Romanian Journal of Laboratory Medicine, 2015
Determinarea concentraţiilor in vivo ale monoxidului de azot (NO) este necesară pentru identificarea condiţiilor patologice în care producţia endogenă a acestui compus este redusă sau pentru identificarea unor agenţi care pot genera in vivo acest compus.
Croitoru Mircea Dumitru, Fülöp Ibolya, Fogarasi Erzsébet, Muntean Daniela-Lucia   +3 more
doaj   +1 more source

Nitrate in drinking water and colorectal cancer risk: A nationwide population‐based cohort study

International Journal of Cancer, 2018
Nitrate in drinking water may increase risk of colorectal cancer due to endogenous transformation into carcinogenic N‐nitroso compounds. Epidemiological studies are few and often challenged by their limited ability of estimating long‐term exposure on a ...
J. Schullehner, B. Hansen, M. Thygesen, C. Pedersen, T. Sigsgaard   +4 more
semanticscholar   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Influence of the origin on selected determinants of the quality of pork meat products

Czech Journal of Food Sciences, 2013
in recent years, great attention has been paid to the quality of eaten meat and its products. There have been launched a lot of promotional campaigns aimed at providing opportunities for the consumption of traditional products. Based on the experiment, a
Bożena GARBOWSKA, Monika RADZYMIŃSKA, Dominika JAKUBOWSKA   +2 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

The effect of chloride and sulphate application to soil on changes in nutrient content in barley shoot biomass at an early phase of growth

Plant, Soil and Environment, 2004
In this study experiments primarily aimed at the needs of specification of an adequate soil reserve of labile sulphur were extended by investigations of the impact on interactions in nutrient uptake by a test barley plant. Vegetation (18-day) experiments
J. Matula
doaj   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Determination of Phenol in Hypersaline Groundwater by Continuous Flow Analysis Method

Yankuang ceshi, 2019
BACKGROUND Determination of phenol by the continuous flow analysis method is seriously compromised if the contents of chlorides or nitrates are greater than 0.4g/L in groundwater.
GU Hua, SHAN Xiao-feng, CUI Jun, ZHANG Qiang, YU Xiao-feng, ZHU Ge   +5 more
doaj   +1 more source

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source