Results 71 to 80 of about 350,994 (296)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Effects of different nitrate sources on in vitro rumen fermentation, methane production, and the microbiome

Italian Journal of Animal Science
Nitrate (NO3−) serves as a microbial non-protein nitrogen source and as a methanogen and methanogenesis inhibitor. Nitrate salts exhibit varying solubilities depending on their constituent cations, which could influence their metabolic utilisation by ...
JongMin Kim, HanBeen Kim, SiWoo Jeong, Jakyeom Seo   +3 more
doaj   +1 more source

Transcriptome and Metabolome Analyses Reveal That Nitrate Strongly Promotes Nitrogen and Carbon Metabolism in Soybean Roots, but Tends to Repress It in Nodules

Plants, 2018
Leguminous plants form root nodules with rhizobia that fix atmospheric dinitrogen (N2) for the nitrogen (N) nutrient. Combined nitrogen sources, particular nitrate, severely repress nodule growth and nitrogen fixation activity in soybeans (Glycine max [L.
Shinji Ishikawa, Yuki Ono, Norikuni Ohtake, Kuni Sueyoshi, Sayuri Tanabata, Takuji Ohyama   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Root extracts of Bracchiaria humidicola andSaccharum spontaneum to increase N use by sugarcane

Scientia Agricola, 2016
Retaining the mineral N in the form of NH4+ in the soil for a lengthy period is desirable for reducing losses. Furthermore, there is evidence that sugarcane prefers NH4+-N in place of NO3−-N.
Oriel Tiago Kölln, Henrique Coutinho Junqueira Franco, Danilo Alves Ferreira, Vitor Paulo Vargas, Saulo Augusto de Quassi Castro, Heitor Cantarella, Camila Caldana, Paulo Cesar Ocheuze Trivelin   +7 more
doaj   +1 more source

Grapefruit juice enhances the systolic blood pressure‐lowering effects of dietary nitrate‐containing beetroot juice [PDF]

, 2020
Kevin O’Gallagher, Sarah Borg Cardona, Callum A. S. Hill, Ali K. Alsaedi, Fawzia Shahed, Christopher N. Floyd, K. McNeill, Charlotte Mills, David J. Webb   +8 more
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Associations between environmental perchlorate, nitrate, and thiocyanate exposure and severe headache or migraine: a cross-sectional, population-based analysis

Frontiers in Neurology
BackgroundEnvironmental contaminants may play a significant role in the development of migraine. Perchlorate, nitrate, and thiocyanate were selected for this study due to their known impact on thyroid function, which is closely linked to neurological ...
Jiesheng Mao, Mi Zhou, Li Yanjun, Yunhan Zhao, Haoxiang Hu, Xiaokai Yang   +5 more
doaj   +1 more source

Functional Quality, Mineral Composition and Biomass Production in Hydroponic Spiny Chicory (Cichorium spinosum L.) Are Modulated Interactively by Ecotype, Salinity and Nitrogen Supply

Frontiers in Plant Science, 2019
The hydroponic cultivation of spiny chicory (Cichorium spinosum L.), also known as stamnagathi, allows the development of year-round production. In the current study, two contrasting stamnagathi ecotypes originating from a montane and a coastal-marine ...
Martina Chatzigianni, Martina Chatzigianni, Georgia Ntatsi, Georgia Ntatsi, Maria Theodorou, Aristidis Stamatakis, Ioannis Livieratos, Youssef Rouphael, Dimitrios Savvas   +8 more
doaj   +1 more source

PdCu Electrocatalysts for Selective Nitrate and Nitrite Reduction to Nitrogen

, 2022
Jeonghoon Lim, Yu Chen, David A. Cullen, Seung Woo Lee, Thomas P. Senftle, Marta C. Hatzell   +5 more
openalex   +2 more sources