Results 111 to 120 of about 558,186 (382)

Metabolic Impacts of Using Nitrogen and Copper-Regulated Promoters to Regulate Gene Expression in Neurospora crassa. [PDF]

, 2015
The filamentous fungus Neurospora crassa is a long-studied eukaryotic microbial system amenable to heterologous expression of native and foreign proteins. However, relatively few highly tunable promoters have been developed for this species.
Beecher, Consuelo N, Borkovich, Katherine A, Larive, Cynthia K, Ouyang, Shouqiang, Wang, Kang   +4 more
core   +1 more source

Compensatory periplasmic nitrate reductase activity supports anaerobic growth of Pseudomonas aeruginosa PAO1 in the absence of membrane nitrate reductase.

Canadian Journal of Microbiology (print), 2009
Nitrate serves as a terminal electron acceptor under anaerobic conditions in Pseudomonas aeruginosa. Reduction of nitrate to nitrite generates a transmembrane proton motive force allowing ATP synthesis and anaerobic growth.
Nadine E Van Alst, Lani A Sherrill, B. Iglewski, C. Haidaris   +3 more
semanticscholar   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

High Turnover Frequency in the Electrocatalytic Reduction of Nitrous Oxide to Dinitrogen at a Binuclear Copper Complex of 3,5‐Diamino‐1,2,4‐Triazole

Angewandte Chemie, EarlyView.
Inspired by nitrous oxide reductase, a binuclear copper complex supported by carbon black was utilized for the electrocatalytic N₂O reduction under ambient conditions. The binuclear Cu center enables exceptionally high turnover frequency and nearly 100% Faradaic efficiency for the electrochemical N₂O reduction.
Zhengwei Ma, Masaru Kato, Jenny Pirillo, Yuh Hijikata, Takeshi Watanabe, Yohei Uemura, Bang Lu, Satoru Takakusagi, Ken'ichi Kimijima, Hideo Notsu, Ichizo Yagi   +10 more
wiley   +2 more sources

A dedicated haem lyase is required for the maturation of a novel bacterial cytochrome c with unconventional covalent haem binding [PDF]

, 2007
In bacterial c-type cytochromes, the haem cofactor is covalently attached via two cysteine residues organized in a haem c-binding motif. Here, a novel octa-haem c protein, MccA, is described that contains only seven conventional haem c-binding motifs ...
Allen J.W.A., Allen J.W.A., Allen J.W.A., Allen J.W.A., Beliaev A.S., de Vitry C., Dobbin P.S., Hartshorne S., Kroger A., Lorenzen J.P., Mileni M., Moore G.R., Mowat C.G., Scott R.A., Thony-Meyer L., Walker F.A., Wood P.M., Yang F.   +17 more
core   +1 more source

Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults

Advanced Science, EarlyView.
This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng, Yuening Cao, Senmiao Ren, Chaozheng Zhang, Jianan Liu, Ke Liu, Yan Wang, Hongyu Chen, Fengjiao Zhou, Xiuli Yang, Xian Ge, Tingting Zhang, Tianbao Wang, Yao He, Defang Li, Chuantao Zhang, Jun Lu   +16 more
wiley   +1 more source

Omeprazole Treatment Enhances Nitrogen Use Efficiency Through Increased Nitrogen Uptake and Assimilation in Corn

Frontiers in Plant Science, 2019
Omeprazole is a selective proton pump inhibitor in humans that inhibits the H+/K+-ATPase of gastric parietal cells. Omeprazole has been recently shown to act as a plant growth regulator and enhancer of salt stress tolerance.
Michael James Van Oosten, Emilia Dell’Aversana, Alessandra Ruggiero, Valerio Cirillo, Yves Gibon, Pasqualina Woodrow, Albino Maggio, Petronia Carillo   +7 more
doaj   +1 more source

Nitrous oxide production in soil isolates of nitrate-ammonifying bacteria [PDF]

, 2012
Here we provide the first demonstration of the potential for N2O production by soil-isolated nitrate-ammonifying bacteria under different C and N availabilities, building on characterizations informed from model strains.
Bamford, Bleakley, Cole, Costa, Cruz Ramos, Fazzolari, Gilberthorpe, Hussain, Iobbi-Nivol, Jepson, Jormakka, Kelso, Lane, Macdonald, Mohan, Nakano, Pett-Ridge, Pope, Potter, Sambrook, Schmidt, Silver, Silver, Simon, Smith, Smith, Smith, Stevens, Wan, Yin   +29 more
core   +2 more sources

NIN-like protein 8 is a master regulator of nitrate-promoted seed germination in Arabidopsis

Nature Communications, 2016
Seeds respond to multiple different environmental stimuli that regulate germination. Nitrate stimulates germination in many plants but how it does so remains unclear.
Dawei Yan, Vanathy Easwaran, V. Chau, Masanori Okamoto, Matthew Ierullo, M. Kimura, A. Endo, R. Yano, A. Pasha, Y. Gong, Y. Bi, N. Provart, D. Guttman, A. Krapp, S. Rothstein, E. Nambara   +15 more
semanticscholar   +1 more source