Results 101 to 110 of about 91,152 (296)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Omeprazole Treatment Enhances Nitrogen Use Efficiency Through Increased Nitrogen Uptake and Assimilation in Corn

Frontiers in Plant Science, 2019
Omeprazole is a selective proton pump inhibitor in humans that inhibits the H+/K+-ATPase of gastric parietal cells. Omeprazole has been recently shown to act as a plant growth regulator and enhancer of salt stress tolerance.
Michael James Van Oosten, Emilia Dell’Aversana, Alessandra Ruggiero, Valerio Cirillo, Yves Gibon, Pasqualina Woodrow, Albino Maggio, Petronia Carillo   +7 more
doaj   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Minimal ATP‐Independent N2‐Reducing Systems Defined by L‐Cluster‐Bound Nitrogenase Assembly Platforms

Angewandte Chemie, EarlyView.
Association of the L‐cluster with the nitrogenase assembly proteins NifEN (NifENL) or NifB (NifBL) intrinsically endows these proteins with N2‐reducing activity, enabling in vitro N2‐reduction by NifENL and NifBL when supplied with chemical reductants or photoexcited quantum dots while supporting in vivo N2‐fixation in NifENL‐ and NifENL‐expressing ...
Robert Quechol, Yimo Yang, Chi Chung Lee, Markus W. Ribbe, Yilin Hu   +4 more
wiley   +2 more sources

Purification and Characterization of Nitrate Reductase (NAR) from Pseudomonas sp. SH7 Isolate

مجلة مركز بحوث التقنيات الاحيائية, 2010
Sixty five soil samples and fifteen water samples were collected from different places in which previously explosions were occurred in Iraq. Seven isolates showed ability to utilize 0.1mM trinitrotoluene (TNT) and/or 0.2mM glycerol trinitrate (GTN) as a
Shaymaa H. Al-Rajhi, Majed H. Al-Gelawi, Ghazi M. Aziz   +2 more
doaj   +1 more source

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source

A novel mechanism for dissimilatory nitrate reduction to ammonium in Acididesulfobacillus acetoxydans

mSystems
The biological route of nitrate reduction has important implications for the bioavailability of nitrogen within ecosystems. Nitrate reduction via nitrite, either to ammonium (ammonification) or to nitrous oxide or dinitrogen (denitrification), determines
Reinier A. Egas, Julia M. Kurth, Sjef Boeren, Diana Z. Sousa, Cornelia U. Welte, Irene Sánchez-Andrea   +5 more
doaj   +1 more source

The uptake and accumulation of phosphorous and nitrates and the activity of nitrate reductase in cucumber seedlings treated with PbCl2 or CdCl2

Acta Societatis Botanicorum Poloniae, 2014
Treatment of 4-day-old cucumber (Cucumis sativus L.) seedlings with PbCl2 or CdCl2 caused a significant increase in the accumulation of heavy metals by the plants, especially in the roots.
Marek Burzyński
doaj   +1 more source

Evaluating two concepts for the modelling of intermediates accumulation during biological denitrification in wastewater treatment [PDF]

, 2015
The accumulation of the denitrification intermediates in wastewater treatment systems is highly undesirable, since both nitrite and nitric oxide (NO) are known to be toxic to bacteria, and nitrous oxide (N2O) is a potent greenhouse gas and an ozone ...
Bing-Jie Ni, David Richardson, Henze, Hiatt, Huijie Lu, IPCC, Kartik Chandran, Kucera, McMurray, Ni, Ni, Oh, Pan, Pan, Pan, Pan, Ravishankara, Reichert, Richardson, Schalk-Otte, Schulthess, Tchobanoglous, Vonschulthess, Yuting Pan, Zhiguo Yuan, Zumft   +25 more
core   +1 more source