Protein NirP1 regulates nitrite reductase and nitrite excretion in cyanobacteria [PDF]
Nature CommunicationsWhen the supply of inorganic carbon is limiting, photosynthetic cyanobacteria excrete nitrite, a toxic intermediate in the ammonia assimilation pathway from nitrate.
Alexander Kraus +7 more
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Endothelial alpha globin is a nitrite reductase [PDF]
Nature Communications, 2022 In mammals, hypoxia causes dilation of small arteries for increased metabolic demand. Keller et al used novel transgenic mice to show alpha hemoglobin in endothelium, once thought only in red blood cells, can regulate hypoxic-mediated dilation.
T. C. Stevenson Keller +28 more
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Structure and mechanism of copper–carbonic anhydrase II: a nitrite reductase [PDF]
IUCrJ, 2020 Nitric oxide (NO) promotes vasodilation through the activation of guanylate cyclase, resulting in the relaxation of the smooth muscle vasculature and a subsequent decrease in blood pressure.
Jacob T. Andring +2 more
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Engineering neuroglobin nitrite reductase activity based on myoglobin models [PDF]
Biochemistry and Biophysics Reports, 2023 Neuroglobin is a hemoprotein expressed in several nervous system cell lineages with yet unknown physiological functions. Neuroglobin presents a very similar structure to that of the related globins hemoglobin and myoglobin, but shows an hexacoordinate ...
Mark D. Williams +3 more
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Ampere-level current density ammonia electrochemical synthesis using CuCo nanosheets simulating nitrite reductase bifunctional nature. [PDF]
Nat Commun, 2022 The development of electrocatalysts capable of efficient reduction of nitrate (NO3−) to ammonia (NH3) is drawing increasing interest for the sake of low carbon emission and environmental protection.
Fang JY +8 more
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The Di-Iron Protein YtfE Is a Nitric Oxide-Generating Nitrite Reductase Involved in the Management of Nitrosative Stress. [PDF]
J Am Chem Soc, 2022 Previously characterized nitrite reductases fall into three classes: siroheme-containing enzymes (NirBD), cytochrome c hemoproteins (NrfA and NirS), and copper-containing enzymes (NirK).
Crack JC +8 more
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The Mechanism of Nitrite Reductase. [PDF]
J Comput ChemABSTRACT Cytochrome c nitrite reductase (CcNiR) activates nitrite and produces ammonia. It is one of several enzymes that use a redox‐active cofactor to perform its reaction. In this case, the cofactor has a heme with a lysine as the proximal ligand and a charged nearby arginine.
Siegbahn PEM.
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Study of the Cys-His bridge electron transfer pathway in a copper-containing nitrite reductase by site-directed mutagenesis, spectroscopic, and computational methods [PDF]
, 2018 The Cys-His bridge as electron transfer conduit in the enzymatic catalysis of nitrite to nitric oxide by nitrite reductase from Sinorhizobium meliloti 2011 (SmNir) was evaluated by site-directed mutagenesis, steady state kinetic studies, UV-vis and EPR ...
Brondino, Carlos Dante +7 more
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Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase. [PDF]
PLoS ONE, 2014 Nitrite was recognized as a potent vasodilator >130 years and has more recently emerged as an endogenous signaling molecule and modulator of gene expression. Understanding the molecular mechanisms that regulate nitrite metabolism is essential for its use
Carmen Gherasim +4 more
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An In Silico Analysis of Synthetic and Natural Compounds as Inhibitors of Nitrous Oxide Reductase (N2OR) and Nitrite Reductase (NIR) [PDF]
Toxics, 2023 Nitrification inhibitors are recognized as a key approach that decreases the denitrification process to inhibit the loss of nitrogen to the atmosphere in the form of N2O.
Radhakrishnan Narayanaswamy +4 more
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