Results 101 to 110 of about 149,344 (340)

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

Nucleation kinetics in drying sodium nitrate aerosols [PDF]

open access: yesarXiv, 2019
A quantitative understanding of the evaporative drying kinetics and nucleation rates of aqueous based aerosol droplets is important for a wide range of applications, from atmospheric aerosols to industrial processes such as spray drying. Here, we introduce a numerical model for interpreting measurements of the evaporation rate and phase change of ...
arxiv  

Nitrate of Pilocarpine [PDF]

open access: yesThe Boston Medical and Surgical Journal, 1877
n ...
openaire   +2 more sources

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

open access: yesFEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang   +7 more
wiley   +1 more source

Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria

open access: yesFEBS Open Bio, EarlyView.
The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao   +4 more
wiley   +1 more source

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

open access: yesFEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu   +4 more
wiley   +1 more source

The influence of irrigation on nitrates movement in soil and risk of subsoil contamination

open access: yesSoil and Water Research, 2009
This paper presents the results of the nitrates movement monitoring under the conditions of field experiment, with different fertilisation doses applications, with and without irrigation and, for different crops.
Katarína NOVÁKOVÁ, Dušan NÁGEL
doaj   +1 more source

Shielding resources for four common radiopharmaceuticals utilized for imaging and therapy: Tc‐99m, F‐18, I‐131, and Lu‐177

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction The use of radioactive materials in the United States has been tightly regulated by the Nuclear Regulatory Commission and other entities for many decades. In 2015, however, the Joint Commission began to require hospital‐based nuclear medicine departments to conduct shielding designs and evaluations for radioactive material areas ...
Michael Oumano   +12 more
wiley   +1 more source

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