Results 81 to 90 of about 149,344 (340)

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Evaluation of the Intake of Nitrate, Nitrite, Nitrosodiethylamine and Nitrosodimethylamine by Food Consumption

EQA, 2014
The aim of the present study was the evaluation of nitrate, nitrite, nitrosodiethylamine (NDEA) and nitrosodimethylamine (NDMA) intake by food consumption.
Liliana Avasilcai, Marieta Nichifor, Geanina Bireescu, Rodica Cuciureanu   +3 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Environmental and technological carrot safety conditions. Part I. Changes in the content of nitrates determined by the environment and processing

Environmental Protection and Natural Resources, 2017
The aim of the research was to define changes in the content of NO3¯ determined by the environment and processing in products from five cultivars of carrot, orange in colour.
Wszelaczyńska Elżbieta, Pobereżny Jarosław, Gościnna Katarzyna, Chmielewski Jarosław, Knapowski Tomasz, Kozera Wojciech, Majcherczak Edward   +6 more
doaj   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

The effect of iodine and strumigens long-term foodborne intake on histometrical parameters of thyroid gland in gimmers

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013
In 2010 and 2011 two experiments on gimmers of Šumava mountain sheep were performed. The first experiment was carried out on 12 animals (experimental period was 11 months); control group was fed with 3 mg I*kg−1 in dry matter per day and experimental ...
Zdeněk Peksa, Jan Trávníček, Roman Konečný, František Jelínek, Hana Dušová, Kateřina Volfová, Aneta Vrbová, Luboš Zábranský, Daniel Falta, Václav Pálka   +9 more
doaj   +1 more source

Norfloxacinium nitrate

IUCrData
In the title salt [systematic name: 4-(3-carboxy-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)piperazin-1-ium nitrate], C16H19FN3O3 +·NO3 −, proton transfer from nitric acid to the N atom of the piperazine ring of norfloxacin has occurred to form a molecular salt.
Abdusamat Rasulov, Batirbay Torambetov, Bekmurod Alimnazarov, Shakhnoza Kadirova, Jabbor Suyunov, Yusufjon Nazarov, Jamshid Ashurov   +6 more
openaire   +3 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Presence of nitrates in baby foods marketed in Portugal

Cogent Food & Agriculture, 2015
This study was carried out to determine the current levels of nitrates in baby foods marketed in Lisbon, Portugal to estimate the toxicological risk associated with their intake. The nitrate content was determined in bottled baby foods of four varieties:
João Sebastião Rebelo, Mário Dias Almeida, Lucília Vales, Cristina M. M. Almeida   +3 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source