Results 61 to 70 of about 2,342 (296)

DRINKING WATER QUALITY IN WELLS FROM AN AREA AFFECTED BY FLOOD EVENTS: CASE STUDY OF CURVATURE SUB-CARPATHIANS, ROMANIA [PDF]

Aerul şi Apa: Componente ale Mediului, 2015
The present study evaluates the chemical parameters (inorganic anions and metals) of drinking water of twenty-four wells and the presence of Escherichia coli in ten selected wells located in two villages from Buzau and Prahova Counties, in Curvature Sub ...
ŞENILĂ M., SIMA MIHAELA, LEVEI ERIKA, ROMAN M., ŞENILĂ LĂCRIMIOARA, HOAGHIA ALEXANDRA, MICU DANA, CADAR OANA, BĂLTEANU D.   +8 more
doaj   +1 more source

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase [PDF]

Nature Chemical Biology, 2014
Iron-dependent halogenases employ cis-halo-Fe(IV)-oxo (haloferryl) complexes to functionalize unactivated aliphatic carbon centers, a capability elusive to synthetic chemists. Halogenation requires (i) coordination of a halide anion (Cl(-) or Br(-)) to the enzyme's Fe(II) cofactor, (ii) coupled activation of O2 and decarboxylation of α-ketoglutarate to
Megan L Matthews, Wei-chen Chang, Andrew P Layne, Linde A Miles, Carsten Krebs, J Martin Bollinger   +5 more
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Agricultural impacts on streams near Nitrate Vulnerable Zones: A case study in the Ebro basin, Northern Spain.

PLoS ONE, 2019
Agricultural intensification during the last century has caused river degradation across Europe. From the wide range of stressors derived from agricultural activities that impact rivers, diffuse agricultural pollution has received most of the attention ...
Rubén Ladrera, Oscar Belmar, Rafael Tomás, Narcís Prat, Miguel Cañedo-Argüelles   +4 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Nitrates Directive [PDF]

This paper examines the nitrogen concentration in groundwater in Slovenia, Slovakia, and Czechia between 2000 and 2019 using panel data. The model consist of the dependent variable WaterQuality, the independent variable Nitrates Directive, five control ...
Hult, Ebba
core  

Biological monitoring of aquatic ecosystems in Italy

Journal of Limnology, 2001
In Italy, Ecotoxicology has found a place with the Legislative Decree n. 152 (May 11, 1999), emanated in fulfilment of the Directives 91/271/CEE "urban waste-water treatment" and 91/676/CEE "protection of waters against pollution caused by nitrates from ...
Renato BAUDO
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source