Platelet inhibitory effects of the Phase 3 anticancer and normal tissue cytoprotective agent, RRx-001. [PDF]
, 2018 The platelet inhibitory effects of the Phase 3 anticancer agent and nitric oxide (NO) donor, RRx-001, (1-bromoacetyl-3,3-dinitroazetidine) were examined ex vivo and compared with the diazeniumdiolate NO donor, diethylenetriamine NONOate (DETA-NONOate ...
Bryan Oronsky +3 more
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Proceedings of the Society for Experimental Biology and Medicine, 2000 Abstract.Nitric oxide (NO) donors are pharmacologically active substances that release NOin vivoorin vitro. NO has a variety of functions such as the release of prostanoids, inhibition of platelet aggregation, effect on angiogenesis, and production of oxygen free radicals.
Tadahiko Yamamoto, Richard J. Bing
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The Role of Nitric Oxide in Skeletal Simulated Microgravity Response [PDF]
, 2015 Prolonged exposure to the space environment leads to bone loss. Using a ground-based model for microgravity (hind-limb unloading), it has been shown in rodents that proliferation and differentiation activity of osteoprogenitors are decreased with ...
Tran, Luan
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Coupling Between the Thermosphere and the Stratosphere: the Role of Nitric Oxide [PDF]
, 1984 In order to understand the lower ionosphere and its probable control by dynamical processes, the behavior of nitric oxide below 100 km was investigated. A two dimensional model with coupled chemical and dynamical processes was constructed.
Brasseur, G.
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Robert F. Furchgott, Nobel laureate (1916-2009) - a personal reflection [PDF]
, 2009 Robert F. Furchgott, pharmacologist and joint winner of the Nobel Prize for Medicine or Physiology (1998) died on the 12th of May 2009 aged 92. By unlocking the astonishingly diverse biological actions of nitric oxide, Furchgott leaves behind a rich ...
Ambache +40 more
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Therapeutic strategies to address neuronal nitric oxide synthase deficiency and the loss of nitric oxide bioavailability in Duchenne Muscular Dystrophy. [PDF]
, 2017 Duchenne Muscular Dystrophy is a rare and fatal neuromuscular disease in which the absence of dystrophin from the muscle membrane induces a secondary loss of neuronal nitric oxide synthase and the muscles capacity for endogenous nitric oxide synthesis ...
Hayes, Alan +2 more
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Theoretical Analysis of Nitric Oxide Production in a Methane/Air Turbulent Diffusion Flame [PDF]
, 1980 The coherent flame model is applied to the methane-air turbulent diffusion flame with the objective of describing the production of nitric oxide. The example of a circular jet of methane discharging into a stationary air atmosphere is used to illustrate ...
Marble, Frank E.
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Platelet anesthesia with nitric oxide with or without eptifibatide during cardiopulmonary bypass in baboons [PDF]
, 1999 Objective:This study tested the hypothesis that nitric oxide or nitric oxide and eptifibatide (Integrilin) reversibly inhibit platelet activation and consumption during cardiopulmonary bypass and rapidly restore platelet numbers and function after bypass.
Edmunds, L.Henry +6 more
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Osteoarthritis and nitric oxide
Osteoarthritis and Cartilage, 2008 Osteoarthritis (OA) is caused by both biochemical and mechanical factors. While the mechanisms that underlie the disease are not completely understood, investigators have characterized a number of catabolic and protective factors that have a role in the disease process.
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Nitric oxide and nitric oxide synthase in Huntington's disease [PDF]
Journal of Neuroscience Research, 2001 AbstractNitric oxide (NO) is a biologically active inorganic molecule produced when the semiessential amino acid l‐arginine is converted to l‐citrulline and NO via the enzyme nitric oxide synthase (NOS). NO is known to be involved in the regulation of many physiological processes, such as control of blood flow, platelet adhesion, endocrine function ...
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