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Nitric Oxide

The American Journal of the Medical Sciences, 1993
Nitric oxide is a newly discovered gas that mediates communication between adjacent cells and signals inside cells. Defects in the nitric oxide signalling cascade have been found in patients with systemic hypertension, pulmonary hypertension, and coronary artery disease. High concentrations of nitric oxide are cytotoxic. Over-production of nitric oxide
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Sepsis and Nitric Oxide

1996
Sepsis or the septic syndrome is the number one cause of mortality in todays intensive care. Overall mortality of sepsis is estimated to be 40 to 60% and when shock or organ failure is present mortality rate is even higher despite recent progress in antibiotic and vasopressor therapy (Bone et al. 1991).
Avontuur, J, Bruining, HA, Ince, Can
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Exhaled Nitric Oxide

Immunology and Allergy Clinics of North America, 2007
Nitric oxide (NO) is now considered an important biomarker for respiratory disease. Studies have confirmed that the fractional concentration of exhaled nitric oxide (FENO) is elevated in the airways of patients who have asthma in comparison with controls.
Lora, Stewart, Rohit, Katial
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Nitric Oxide in the Airways

The Journal of Allergy and Clinical Immunology: In Practice, 2007
This review briefly explains the basic facts about nitric oxide, which is entering clinical practice as a measure of lower airways inflammation and is likely also to be employed in otorhinolaryngological practice.These include the validity of nasal nitric oxide in diagnosing primary ciliary dyskinesia and in monitoring the response to chronic ...
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Inhaled nitric oxide

Seminars in Perinatology, 2000
Nitric oxide (NO) is a free-radical gas that is an important signaling molecule in pulmonary vessels. Endogenous NO produced in endothelial cells from oxygen and L-arginine diffuses into smooth muscle cells in the vascular wall and causes vasodilatation.
J D, Roberts, W M, Zapol
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Oxidized lipoproteins and nitric oxide

Current Opinion in Lipidology, 1996
Nitric oxide has an important biological role as endothelium-derived relaxing factor, a key agent in the maintenance of normal vascular tone. It can also suppress lipoprotein oxidation, a potential anti-atherogenic property. However, in arteries subject to hypercholesterolemia or atherosclerosis, whereas nitric oxide synthesis is normal its biological ...
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Nitric Oxide and Apoptosis

1997
Apoptosis occurs during normal development of an organism but also plays an important role under pathophysiological conditions. Nitric oxide (NO) exhibits a double-edged role in apoptosis induction. Both pro- and antiapoptotic effects of NO have been demonstrated. The proapoptotic effects appear to be linked to pathophysiological conditions, where high
J, Haendeler, A M, Zeiher, S, Dimmeler
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Nitric Oxide Donors

Proceedings of the Society for Experimental Biology and Medicine, 2000
Abstract.Nitric oxide (NO) donors are pharmacologically active substances that release NOin vivoorin vitro. NO has a variety of functions such as the release of prostanoids, inhibition of platelet aggregation, effect on angiogenesis, and production of oxygen free radicals.
T, Yamamoto, R J, Bing
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Nitric Oxide in Atherosclerosis

Mini-Reviews in Medicinal Chemistry, 2002
*NO is produced endogenously from L-arginine by NOSs. Among its multiple activities, the homeostatic control of the vascular endothelium is crucial for atherosclerosis, a pathogenic condition connected with elevated levels of LDL, the main plasma cholesterol carrier.
E A, Rekka, M C, Chrysselis
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Nitric oxide in rheumatology

Joint Bone Spine, 2001
Nitric oxide (NO) is attracting considerable interest because it mediates many functions. This gas is ubiquitously produced in the body by three enzymes, called NO synthases. Two NO synthases are constitutively expressed, one in the nervous system and the other in the blood vessels, where it regulates tissue perfusion.
C, Bernardeau   +4 more
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