Results 41 to 50 of about 3,846,165 (408)
Kidney International, 2007 Refractory hypotension with end-organ hypoperfusion and failure is an ominous feature of shock. Distributive shock is caused by severe infections (septic shock) or severe systemic allergic reactions (anaphylactic shock). In 1986, it was concluded that nitric oxide (NO) is the endothelium-derived relaxing factor that had been discovered 6 years earlier.
openaire +3 more sources
Exercise training and losartan improve endothelial function in heart failure rats by different mechanisms [PDF]
, 2013 Objectives. To investigate the mechanisms of losartan- and exercise training-induced improvements on endothelial dysfunction in heart failure. Design. Sprague-Dawley rats subjected to left coronary artery ligation inducing myocardial infarction and heart
Crozier I +5 more
core +1 more source
Antioxidants, 2019 Low temperature (LT) negatively affects plant growth and development via the alteration of the metabolism of reactive oxygen and nitrogen species (ROS and RNS).
Juan C. Begara-Morales +8 more
doaj +1 more source
Agronomy, 2020 Arsenic (As) is a highly toxic metalloid for all forms of life including plants. Rice is the main food source for different countries worldwide, although it can take up high amounts of As in comparison with other crops, showing toxic profiles such as ...
Ernestina Solórzano +3 more
doaj +1 more source
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
Proceedings of the National Academy of Sciences of the United States of America, 1990 Nitric oxide mediates vascular relaxing effects of endothelial cells, cytotoxic actions of macrophages and neutrophils, and influences of excitatory amino acids on cerebellar cyclic GMP.
D. Bredt, S. Snyder
semanticscholar +1 more source
Is there NO treatment for severe sepsis? [PDF]
, 2008 Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
core +2 more sources
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Endothelium and nitric oxide [PDF]
Medicina, 2008 Studied nature of the “blood vessels relaxing factor” derived fromendotheliumthat was identified as nitric oxide caused intensive scientific research on nitric oxide regarding some aspects of its impact on human physiological and pathological processes.
openaire +2 more sources
Platelet inhibitory effects of the Phase 3 anticancer and normal tissue cytoprotective agent, RRx-001. [PDF]
, 2018 The platelet inhibitory effects of the Phase 3 anticancer agent and nitric oxide (NO) donor, RRx-001, (1-bromoacetyl-3,3-dinitroazetidine) were examined ex vivo and compared with the diazeniumdiolate NO donor, diethylenetriamine NONOate (DETA-NONOate ...
Bryan Oronsky +3 more
core +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source