Results 121 to 130 of about 178,919 (340)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type

Journal of Lipid Research, 2006
Long-term dietary fatty acid intake alters the development of left ventricular hypertrophy, but the linking signaling pathways are unclear. We studied the role and underlying signaling mechanisms of dietary fat intake in the early phase of the ...
Gaébor Foäldes, Szilvia Vajda, Zoltaén Lakoé-Futoé, Balaézs Saérmaén, Reéka Skoumal, Mika Ilves, Rudolf deChâtel, Istvaén Karaédi, Mikloés Toéth, Heikki Ruskoaho, Istvaén Lepraén   +10 more
doaj   +1 more source

Elevator‐Like Hollow Channels in Porous Scaffolds Accelerate Vascularized Bone Regeneration via NETs‐Fibrin‐Mediated Macrophage Recruitment

Advanced Science, EarlyView.
This study demonstrates that how hollow‐channel scaffolds promote vascularized bone regeneration via an immunomodulatory mechanism. The channel structures facilitate the formation of a neutrophil extracellular traps‐fibrin scaffold that recruits vascular endothelial growth factor A (VEGF‐A)‐secreting M2 macrophages to drive angiogenesis. Combining this
Guifang Wang, Rongpu Liu, Huijing Ma, Shuhan Duan, Guangzheng Yang, LingXi Meng, Yuqin Qiao, Dongqiang Song, Wenjie Zhang   +8 more
wiley   +1 more source

Bench-to-bedside review : targeting antioxidants to mitochondria in sepsis [PDF]

, 2010
Peer reviewedPublisher ...
A Dhanasekaran, A Dyson, A Filipovska, AL Hill, AM James, B Bedogni, BE Minter, CA Macias, CC Chuang, CE Cross, D Brealey, D Brealey, D Brealey, D Graham, DA Lowes, DA Lowes, DP Jones, E Borrelli, ED Crouser, ED Crouser, F Arnalich, FN Gellerich, G Escames, G Escames, GF Kelso, GS Supinski, H Bayir, H Bohrer, H Zhang, HC Cowley, Helen F Galley, HF Galley, HF Galley, HF Galley, HF Goode, I Spasojević, I Vanhorebeek, J Ripcke, JC Marshall, JF Turrens, JJ Pandit, JV Esplugues, K Yassen, K Zhao, KS Roser, L Packer, M Qunitero, MD Wheeler, MD Wheeler, MP Fink, MP Fink, MP Murphy, MW Fariss, P Ghafourifar, P Wipf, RAJ Smith, RAJ Smith, RL Paterson, RO Poyton, S González-Rubio, S Rinaldi, SS Sheu, V Mishra, V Vanasco, VJ Adlam, VP Skulachev, W Droge, Z Lacza   +67 more
core   +2 more sources

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Characterisation of type I and type II nNOS-expressing interneurons in the barrel cortex of mouse

Frontiers in Neural Circuits, 2012
In the neocortex, neuronal Nitric Oxide-Synthase (nNOS) is essentially expressed in two sets of GABAergic neurons: type I neurons displaying a high expression and type II neurons displaying a weaker expression.
Quentin ePerrenoud, Hélène eGeoffroy, Benjamin eGautier, Armelle eRancillac, Fabienne eAlfonsi, Nicoletta eKessaris, Jean eRossier, Tania eVitalis, Thierry eGallopin   +8 more
doaj   +1 more source

Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications [PDF]

, 2017
The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase.
Ahmed, S. Faisal, Alves-Lopes, Rheure, Lucas-Herald, Angela K., Montezano, Augusto C., Touyz, Rhian M.   +4 more
core   +1 more source

Injectable Chondroitin Sulfate Methacrylate Hydrogel Microspheres Co‐Loaded with GLPM Nanozyme, Dexamethasone, and Stem Cells for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
A multifunctional injectable microsphere system is fabricated via UV‐assisted microfluidic cross‐linking, integrating nanozyme‐based ROS scavenging, sustained dexamethasone release, and stem cell delivery. Upon IA injection, the microspheres adapt to joint stress, suppress inflammation, and promote cartilage regeneration, offering a minimally invasive ...
Xiaochen Feng, Ying Fang, Hongwei Yu, Yicheng Wang, Yunze Xu, Chunxiao Shi, Haike Xia, Ranjith Kumar Kankala, Aizheng Chen, Shibin Wang, Chaoping Fu   +10 more
wiley   +1 more source

Chronic Production of Peroxynitrite in the Vascular Wall Impairs Vasorelaxation Function in SHR/NDmcr-cp Rats, an Animal Model of Metabolic Syndrome

Journal of Pharmacological Sciences, 2009
We have previously reported that peroxynitrite is involved in dysfunction of nitric oxide (NO)-mediated vasorelaxation in SHR/NDmcr-cp rats (SHR-cp), which display typical symptoms of metabolic syndrome.
Satomi Kagota, Yukari Tada, Namie Nejime, Kazuki Nakamura, Masaru Kunitomo, Kazumasa Shinozuka   +5 more
doaj   +1 more source

Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis. [PDF]

, 2018
To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed.
Aston, Barnes, Chan, Daniel Pastorius, Daniel Smith, Dweik, Eduardo Ticona, Elmasri, Idh, Jon S. Friedland, José W. López, Karina M. Romero, Kim, Lim, Luz Caviedes, Maria-Cristina I. Loader, Marjory Bravard, Moore, Olin, O’Garra, Ralph, Ralph, Robert H. Gilman, Schon, Taryn Clark, Van Beek, Wang, William Checkley, Yhi   +28 more
core   +1 more source