Results 181 to 190 of about 437,208 (310)

Effects of Hormone Replacement Treatment with Estrogen and Progestins on the Vascular Renin-Angiotensin System of Ovariectomized Rats. [PDF]

Int J Mol Sci
Menezes LA, Endlich PW, Lima DSS, Peluso AA, de Almeida SA, Borgo MV, Santos RAS, de Abreu GR.   +7 more
europepmc   +1 more source

Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular‐Related Complications

Molecular Nutrition &Food Research, EarlyView.
(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez, Antonio Vico‐Padilla, Claus Schneider, Juan Carlos Espín, Antonio González‐Sarrías, Juan Antonio Giménez‐Bastida   +5 more
wiley   +1 more source

The Ever-Expanding Influence of the Endothelial Nitric Oxide Synthase. [PDF]

Basic Clin Pharmacol Toxicol
Rafea R, Siragusa M, Fleming I.
europepmc   +1 more source

Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases

Neuroprotection, EarlyView.
The abstract depicts the gut‐brain axis, illustrating the bidirectional communication between the gastrointestinal tract and the central nervous system. Probiotics can induce the production of neurotrophins, neurotransmitters, SCFAs, and contribute to increased antioxidant levels, which can benefit brain health. In contrast, antibiotics can disrupt the
Tobiloba S. Olajide, Omamuyovwi M. Ijomone   +1 more
wiley   +1 more source

Inhibition of hepatic gluconeogenesis in type 2 diabetes by metformin: complementary role of nitric oxide. [PDF]

Med Gas Res
Farahani A, Farahani A, Kashfi K, Ghasemi A.   +3 more
europepmc   +1 more source

Ibuprofen‐Functionalized Alkyl α‐hydroxy Methacrylate‐Based Polymers

ChemistryOpen, EarlyView.
This work describes the synthesis and evaluation of novel alkyl α‐hydroxymethacrylate‐based ibuprofen‐functionalized prodrugs to improve the bioavailability, decrease toxicity, and control drug release. Novel alkyl α‐hydroxymethacrylate‐based prodrugs are prepared to improve bioavailability, decrease toxicity, and control drug release.
Burcu Balaban, Seckin Altuncu, Aleyna Esenturk, Simay Denizkusu, Ece Sabuncu, Hande Sipahi, Duygu Avci   +6 more
wiley   +1 more source

Reassessing the role of nitric oxide in the pathogenesis of sphincter of Oddi dysfunction. [PDF]

Gastroenterol Rep (Oxf)
Lin H, Liang Y, Zhao W, Cao J, Wang T, Wang C.   +5 more
europepmc   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Anti-Inflammatory Mechanisms of <i>Pleurotus citrinopileatus</i>: Inhibition of MAPK and NF-κB Signaling Pathways, and Activation of ROS/PI3K/Nrf2/HO-1 Signaling Pathway in LPS-Stimulated RAW264.7 Cells. [PDF]

J Microbiol Biotechnol
Choi HJ, Choi JW, Park SJ, Lee SH, Hwang JH, Park Y, Lee KT, Jeong JB.   +7 more
europepmc   +1 more source

Iguratimod alleviated Sjögren's syndrome through regulating macrophage polarization

Rheumatology &Autoimmunity, EarlyView.
Nonobese diabetic (NOD) mice exhibited characteristic of Sjögren's syndrome (SS), with increased M1 macrophages and deceased M2 macrophages. Iguratimod alleviated SS‐like symptoms and restored balance of macrophage polarization through inhibiting the mitogen‐activated protein kinases pathway in NOD mice.
Junqiao Guo, Yu Chen, Shumin Wang, Tingting Jiang, Yue Wang, Haolin Wu, Xiaojing Li, Genhong Yao   +7 more
wiley   +1 more source