Results 271 to 280 of about 178,919 (340)

6-Nitrodopamine Release From Mouse Seminal Vesicles Is Dependent on Endothelial Nitric Oxide Synthase (eNOS) Activation. [PDF]

Pharmacol Res Perspect
Britto-Júnior J, Godoy PRC, Lima DO, de Souza VB, Schenka AA, Mariano FV, Jacintho FF, Hermawan I, Shimokawa H, Tsutsui M, Chiavegatto S, Antunes E, De Nucci G.   +12 more
europepmc   +1 more source

The sensory penis: A comprehensive immunohistological and ontogenetic exploration of human penile innervation

Andrology, EarlyView.
Abstract Background Penile sexual sensation relies on intricate neural structures that remain incompletely characterized. Immunohistological insights into their development and organization can enhance understanding of penile neuroanatomy and function, while optimizing surgical outcomes.
Alfonso Cepeda‐Emiliani, María Otero‐Alén, Juan Suárez‐Quintanilla, Marina Gándara‐Cortés, Tomás García‐Caballero, Rosalía Gallego, Lucía García‐Caballero   +6 more
wiley   +1 more source

Potential effect of <i>Commiphora myrrha</i> resin on <i>Eimeria labbeana</i>-like-induced oxidative stress in <i>Columba livia</i> domestica. [PDF]

Front Cell Infect Microbiol
Abdel-Gaber R, Albasyouni S, Santourlidis S, Al Quraishy S, Al-Shaebi E.   +4 more
europepmc   +1 more source

Statin Therapy Independently Reduces Mortality and Liver Complications in Patients With Cirrhosis: An Updated Systematic Review and Meta‐Analysis

Alimentary Pharmacology &Therapeutics, EarlyView.
Statin therapy in cirrhosis may confer a survival benefit while reducing the risk of hepatic decompensation and hepatocellular carcinoma. ABSTRACT Background The role of statins in cirrhosis remains controversial. Historically restricted due to safety concerns, emerging evidence highlights potential pleiotropic benefits, though effects on mortality and
Bernardo de Faria Moraes, Gustavo André Pedral Diniz Leite, Igor Boechat Silveira, Gabriel André Pedral Diniz Leite, Maria Luisa Motta Fonseca, Leonardo Corrêa Suffert, Luisa Medeiros Visentini, Luis Pedro Possapp Beis, Guilherme Grossi Lopes Cançado   +8 more
wiley   +1 more source

Phage PM16 Therapy Induce Long-Term Protective Immunity Against Proteus mirabilis via Macrophage Priming. [PDF]

Pathogens
Al Allaf L, Chechushkov AV, Morozova VV, Kozlova YN, Ushakova TA, Tikunova NV.   +5 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Oral L-Arginine treatment attenuates <i>Cryptococcus neoformans</i> extrapulmonary dissemination and disease progression. [PDF]

Virulence
Hansakon A, Phucharoenrak P, Trachootham D, Kaewrattana S, Jeerawattanawart S, Tangchang W, Chayakulkeeree M, Angkasekwinai N, Angkasekwinai P.   +8 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Glutamine enhances endothelial cell survival and vasodilation by increasing glutathione to reduce oxidative stress. [PDF]

Physiol Rep
Kheradmand M, Sangha G, Sissons CM, Sun M, Zhou X, Smith LV, Bauer M, Chen C, Clyne AM.   +8 more
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source