A Novel Approach for the Synthesis of Peripherally Acting Dual Target Inhibitor of Cannabinoid-1 (CB1 Receptor) and Inducible Nitric Oxide Synthase (iNOS) (<i>S</i>-MRI-1867/Zevaquenabant). [PDF]
MoleculesIyer MR.
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ClC-3 mediates angiotensin II-induced endothelial dysfunction by inhibiting Akt-Hsp90-eNOS signaling pathway. [PDF]
Front PharmacolLi L +6 more
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Aqueous extract of Peristrophe bivalvis leaf alleviates oxidative stress in L-NAME-induced hypertensive rats. [PDF]
BMC Complement Med TherAluko EO, Oyeyemi WA, Fasanmade AA.
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Citrulline-enhanced chicken resistance to <i>Salmonella Enteritidis</i> infection via urea cycle modulation and nitric oxide production. [PDF]
Microbiol SpectrJiang M +9 more
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Copper induces type II nitric oxide synthase in vivo
Free Radical Biology and Medicine, 2003Intravenous administration of copper (up to a final concentration of ca. 35 micromol/l in the plasma) led to a progressive, dramatic fall of mean arterial pressure in rats. Copper-induced pressure changes were comparable to those elicited by 2 mg/kg LPS, and were greatly prevented by previous infusion of the inducible NOS (NOS-II) inhibitors ...
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Leptin induces nitric oxide synthase type II in C6 glioma cells
Neuroscience Letters, 2006Astrocytes in the CNS produce inflammatory mediators in response to several stimuli and cytokines. Here we investigated the in vitro effect of leptin on inducible nitric oxide synthase (iNOS) expression in a glioma cell line (C6). After hormone stimulation, culture media were analysed for accumulated stable oxidation products of NO (NO2(-) and NO3 ...
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Type II nitric oxide synthase activity is cardio-protective in experimental sepsis
European Journal of Pharmacology, 2003Overproduction of nitric oxide (NO) via the induction of NO synthase (NOS) II is implicated in the pathogenesis of the refractory hypotension that characterizes septic shock. However, clinical trials of nonselective NOS inhibitors have failed to afford a mortality benefit in patients with sepsis, and in those with depressed left ventricular function ...
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Nitric Oxide Synthase Type II mRNA Stability Is Translationâ and TranscriptionâDependent
Journal of Neurochemistry, 1996Abstract: Nitric oxide synthase (NOS) type II is induced in many cell types in response to cytokines or endotoxin. The duration of type II NOS mRNA expression in astroglial cells and macrophages in vitro is brief, even in the continuous presence of inducers, and their removal dramatically accelerates mRNA decay.
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Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats
Life Sciences, 2003The goals of this study were to determine the effects of type II diabetes mellitus on nitric oxide synthase-dependent responses of cerebral arterioles and on endothelial nitric oxide synthase (eNOS) protein in cerebral arterioles. We examined dilatation of cerebral (pial) arterioles in 13-15 week old male lean and diabetic obese Zucker rats in response
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Selective type II (inducible) nitric oxide synthase (NOS) inhibitors have several potential therapeutic applications, including treatment of sepsis, diabetes, and autoimmune diseases. The ability of two novel, selective inhibitors of type II NOS, S-ethylisothiourea (EIT) and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), to inhibit type II NOS ...
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