Results 301 to 310 of about 178,919 (340)

Nitric oxide synthase type‐II is synthesized by human gingival tissue and cultured human gingival fibroblasts

Journal of Periodontal Research, 2000
Nitric oxide is known to be an important inflammatory mediator, and is implicated in the pathophysiology of a range of inflammatory disorders. The aim of this study was to determine the localization and distribution of endothelial NOS (NOSII) in human gingival tissue, and to ascertain if human gingival fibroblasts express NOS‐II when stimulated with ...
Kendall, H. K., Haase, H. R., Li, H., Xiao, Y., Bartold, P. M.   +4 more
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Direct Effect of Temperature on the Catalytic Activity of Nitric Oxide Synthases Types I, II, and III

Nitric Oxide, 1999
The effect of temperature (between 5.0 and 45.0 degrees C) on the catalytic activity of nitric oxide synthases types I, II, and III (NOS-I, NOS-II, and NOS-III, respectively) has been investigated, at pH 7.5. The value of V(max) for NOS-I activity increases from 1.8 x 10(1) pmol min(-1) mg(-1), at 5.0 degrees C, to 1.8 x 10(2) pmol min(-1) mg(-1), at ...
VENTURINI G, COLASANTI, Marco, FIORAVANTI E, BIANCHINI A, ASCENZI P.   +4 more
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Production of nitric oxide by rat type II pneumocytes: increased expression of inducible nitric oxide synthase following inhalation of a pulmonary irritant.

American Journal of Respiratory Cell and Molecular Biology, 1994
Nitric oxide is a highly reactive molecule that has been implicated in host defense and tissue injury. In the present studies, we determined whether rat type II alveolar epithelial cells have the capacity to produce this mediator. We found that type II cells synthesize significant quantities of nitric oxide after treatment with the inflammatory ...
C J, Punjabi, J D, Laskin, K J, Pendino, N L, Goller, S K, Durham, D L, Laskin   +5 more
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Cytokine‐induced expression of type II nitric oxide synthase in astrocytes is downregulated by ATP and glutamate

Glia, 1995
AbstractCombinations of cytokines and/or phorbol ester induce expression of Type II nitric oxide synthase (NOS) mRNA in astrocyte cultures via protein kinase mediated pathways (Simmons and Murphy: GLIA 11:227, 1994; Feinstein et al.: J Neurochem 62:811,1994).
S, Murphy, H L, Lin, S K, Park
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Effects of a Nitric Oxide Synthase Type II Inhibitor on Compound Action Potential Thresholds in Experimental Endolymphatic Hydrops

Otology & Neurotology, 2006
Nitric oxide (NO) is likely to be synthesized by nitric oxide synthase Type II (NOS II) action and may partake in the origin of changes of compound action potential (CAP) threshold observed in guinea pigs with induced endolymphatic hydrops. This study aimed to assess the action of a NOS II inhibitor on CAP thresholds in these experimental samples.In ...
Cláudio Márcio Yudi Ikino, Roseli Saraiva Moreira Bittar, Karina Midori Sato, Newton Macuco Capella   +3 more
openalex   +3 more sources

Partial loss of NADPH-diaphorase/nitric oxide synthase-complex in amyotrophic lateral sclerosis and human type-II myofiber atrophy

Neuroscience Letters, 1997
To substantiate the role of nitric oxide synthase type-I (NOS-I) in neurogenic muscular disorders we investigated human biopsy samples of type-II fiber atrophy and amyotrophic lateral sclerosis (ALS) by NOS-I immunoreactivity (-IR), NOS-associated NADPH-dependent diaphorase activity (NOSaD) and Western blot analysis.
B G, Schoser, G, Lück, D, Blottner
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Reduction of penile nitric oxide synthase in diabetic BB/WORdp (type I) and BBZ/WORdp (type II) rats with erectile dysfunction.

Endocrinology, 1995
Erectile dysfunction occurs frequently in human diabetes, and it is sometimes associated with hypogonadism. These conditions also develop in a model of insulin-dependent (type I) diabetes, the BB/WORdp (diabetic prone) rat but have not yet been investigated in the model of insulin-resistant (type II) diabetes, the BBZ/WOR rat.
D, Vernet, L, Cai, H, Garban, M L, Babbitt, F T, Murray, J, Rajfer, N F, Gonzalez-Cadavid   +6 more
openaire   +3 more sources

ENDOTHELIAL NITRIC OXIDE SYNTHASE AND ANGIOTENSIN II TYPE 1 RECEPTOR GENE POLYMORPHISMS CAN INFLUENCE CHRONIC INFLAMMATORY STATE IN RENAL TRANSPLANT PATIENTS

Transplantation, 2004
Serum C-reactive protein (CRP) is a sensitive indicator of inflammation. Because increasing evidence shows the effect of endothelial nitric oxide synthase (eNOS) and the renin-angiotensin system on inflammation, we studied the association among chronic inflammation, chronic rejection, and gene polymorphisms of angiotensin II type 1 receptor (ATR1) and ...
S, Sezer, M, Uyar, A, Akcay, Z, Arat, E, Kulah, F N, Ozdemir, M, Haberal   +6 more
openaire   +2 more sources

Does type II nitric oxide synthase expression correlate with cellular proliferation in oral squamous cell carcinoma and dysplasia?

Head & Neck, 2001
Nitric oxide (NO) has been implicated both in tumor progression and inhibition. This study investigated whether type II nitric oxide synthase (NOS2) expression correlated with cell proliferation in oral squamous cell carcinoma (OSCC) and dysplasia.Paraffin-embedded tissue samples of normal oral mucosa, OSCC, and dysplasia were assessed ...
P A, Brennan, M, Palacios-Callender, G A, Zaki, A V, Spedding, J D, Langdon   +4 more
openaire   +2 more sources

Inducible (type II) nitric oxide synthase in human placental villous tissue of normotensive, pre-eclamptic and intrauterine growth-restricted pregnancies

Placenta, 1997
We have utilized two distinct monospecific antibodies against the type II (macrophage or inducible) nitric oxide synthase (NOS) isoform to localize the distribution of the enzyme within the human placenta in tissues from normotensive pregnancies and those complicated by pre-eclampsia and/or intrauterine growth restriction.
L, Myatt, A L, Eis, D E, Brockman, W, Kossenjans, I, Greer, F, Lyall   +5 more
openaire   +2 more sources