Results 231 to 240 of about 2,976,883 (344)

Late‐Stage Conversion of Terminal Alkynes to Nitriles in Nucleoside Scaffolds: A Tool for Diversification

Asian Journal of Organic Chemistry, EarlyView.
We established a metal‐free, late‐stage diversification of terminal alkynes into nitriles using tert‐butyl nitrite (tBuONO). Replacing 2‐picoline N‐oxide with N‐methylmorpholine N‐oxide (NMO) as the oxidant enabled efficient nitrile formation under mild conditions. Abstract The small nucleoside molecule LJ‐4827 exhibited potent kinase inhibition and in
Yun A Yum, Vikas R. Aswar, Vidyasagar Gaikwad, Sushil K. Tripathi, Dnyandev B. Jarhad, Lak Shin Jeong   +5 more
wiley   +1 more source

Silylative Amide to Nitrile Conversion Mediated by Simple Lanthanide–Organoamides: Scope and Mechanism

Angewandte Chemie, EarlyView.
Described here is a LaNTMS mediated silylative conversion of primary amides to nitriles under neat reaction conditions. The reaction is highly efficient and selective under such solventless conditions, where all materials are commercially available, demonstrating the robustness and potential of lanthanide heteroatom catalysis.
Zhiyu Feng, Qingheng Lai, Yuang Wang, Alessandro Motta, Yosi Kratish, Tobin J. Marks   +5 more
wiley   +2 more sources

Magnetic N-doped CNT stabilized Cu₂O as a catalyst for <i>N</i>-arylation of nitriles and aryl halides in a biocompatible deep eutectic solvent. [PDF]

RSC Adv
Alizadeh M, Salamatmanesh A, Nejad MJ, Heydari A.   +3 more
europepmc   +1 more source

Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide-alkyne 1,3-dipolar cycloaddition.

Organic and biomolecular chemistry, 2010
Virginie Algay, I. Singh, F. Heaney
semanticscholar   +1 more source

Biallelic Variants in the DARS2 Gene as a Novel Cause of Axonal Charcot–Marie–Tooth Disease

Annals of Neurology, EarlyView.
Objective Charcot–Marie–Tooth (CMT) disease is a heterogeneous group of genetic neuropathies, with >90 genes identified. Several aminoacyl‐tRNA synthetases have been linked to CMT. DARS2, encoding the mitochondrial aspartyl‐tRNA synthetase, has been typically associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate ...
Berta Estévez‐Arias, Siiri Sarv, Nathalie Bonello‐Palot, Laura Carrera‐García, Carlos Ortez, Jesica Expósito‐Escudero, Delia Yubero, Jordi Muchart, Emilien Delmont, Eve Õiglane‐Shlik, Teele Meren, Sanna Puusepp, Ülle Murumets, Gajja S. Salomons, Bjarne Udd, Liis Väli, Lara Cantarero, Carsten G. Bönnemann, Andrés Nascimento, Santiago Ramón‐Maiques, Katrin Õunap, Janet Hoenicka, Daniel Natera‐de Benito, Francesc Palau   +23 more
wiley   +1 more source

Computational Study of Ignored Pericyclic Reactions: Rearrangements of 1,2‐Bis(Diazo)Alkanes to 1,2,3,4‐Tetrazines and Subsequent Fragmentations

Angewandte Chemie, EarlyView.
DFT calculations of the 8π‐electrocyclization of 1,2‐bis(diazo)alkanes and of other bis‐1,3‐dipoles reveal that this process can establish a so far ignored route to heterocycles such as 1,2,3,4‐tetrazines. Alternative reaction channels via carbenes or nitrenes leading to fragmentation products are discussed.
Hans‐Ulrich Reissig, Ernst‐Ulrich Würthwein   +1 more
wiley   +2 more sources

Pharmacochemical Studies of Synthesized Coumarin-Isoxazole-Pyridine Hybrids. [PDF]

Molecules
Douka MD, Sigala IM, Gabriel C, Nikolakaki E, Hadjipavlou-Litina DJ, Litinas KE.   +5 more
europepmc   +1 more source

Gloving the Surgeon: <i>A Practical Review of Surgical Glove Material Properties, Safety, and Waste</i>. [PDF]

Ann Surg Open
Patel JJ, Fine KS, O'Shea AW, Wirth PJ, Shaffrey EC, Attaluri PK, Rao VK.   +6 more
europepmc   +1 more source

Low-coordinated Co-Ru dual-atom enables ambient ammoxidation via unlocking competitive adsorption limitations. [PDF]

Nat Commun
Yang J, Fang Z, Sun Z, Zhou W, Nan B, Liu X, Ma Z, Nie R, Fu J.   +8 more
europepmc   +1 more source

Enantioconvergent Deacylative Functionalization toward α-Quaternary Nitriles. [PDF]

Angew Chem Int Ed Engl
Zhang M, Huang Z.
europepmc   +1 more source