Results 211 to 220 of about 2,975,483 (362)

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

open access: yesAdvanced Science, EarlyView.
Elevated levels of the plasticizer DEHP associate with earlier breast cancer diagnosis. DEHP enhances glutamine‐powered energy production via the transporter SLC6A14 and pushes mitochondria toward fusion, driving tumor initiation by boosting cancer stemness. Blocking SLC6A14 lowers stemness, slows tumors, and improves chemotherapy response.
Dai‐Wei Hu   +15 more
wiley   +1 more source

A new approach to heterocycle-modified steroids via nitrile oxide intermediates

open access: diamond, 2008
Alexander V. Baranovsky   +3 more
openalex   +2 more sources

Spatially Resolved Mapping of Voltage‐Gated Proton Channel Activity Reveals Delayed Proton Transport in Local Microenvironments

open access: yesAdvanced Science, EarlyView.
A revolutionary imaging platform integrating quantitative single‐molecule photobleaching with ratiometric fluorescence probes enables high‐throughput (≈2300 individually resolvable channels) mapping of individual proton channels in a large field (≈3000 µm2), overcoming the spatial and temporal limitations of conventional electrophysiology.
Jiahua Zhuang   +5 more
wiley   +1 more source

High Performance Aluminum Ion Batteries Enabled by the Coordination Between Vanadium‐Based PBAs Cathode and Aqueous Eutectic Electrolyte

open access: yesAdvanced Science, EarlyView.
The study proposes a universal strategy for the synthesis of high‐performance vanadium‐based PBAs (V‐PBAs) cathodes for aluminum ion batteries. It is find that the doped transition metals (Fe/Co/Ni) at carbon‐coordinated sites can markedly enhance the multi‐electron redox activity and inhibit the V dissolution, structural collapse, and other ...
Wanchang Feng   +14 more
wiley   +1 more source

Direct Carboboration of Aryl Alkenes with Stable Organoborons Through Ziegler‐Type Addition

open access: yesAdvanced Science, EarlyView.
The direct carboboration of vinyl arenes with benzylic boronates has been achieved using KOtBu as the catalyst. Vinylcyclopropanes and vinylcyclobutane also participate in this reaction, yielding the corresponding 1,5‐ and 1,6‐carboboration products.
Mo Yang   +5 more
wiley   +1 more source

Millikelvin Intracellular Nanothermometry with Nanodiamonds

open access: yesAdvanced Science, EarlyView.
Nanothermometry in living cells is crucial for understanding heat diffusion and advancing cellular biology and drug discovery. Previous studies have reported controversial intracellular temperature variations. Using nanodiamond nanothermometry in macrophages, it is found that, in such experimental setting, apparent temperature changes are actually due ...
Maabur Sow   +26 more
wiley   +1 more source

Chronic PET‐Microplastic Exposure: Disruption of Gut–Liver Homeostasis and Risk of Hepatic Steatosis

open access: yesAdvanced Science, EarlyView.
Chronic exposure to environmentally relevant PET microplastics disrupts gut–liver homeostasis, leading to hepatic steatosis, early fibrosis, and altered gut microbiota. These effects signal metabolic imbalance and gut–liver axis impairment, emphasizing chronic microplastic ingestion as an emerging environmental health risk linked to non‐communicable ...
Surye Park   +5 more
wiley   +1 more source

Electrochemical Approach to Organonitrogen Compounds via C–N Coupling

open access: yesAdvanced Science, EarlyView.
This review summarizes recent advances in electrocatalytic C–N coupling for organonitrogen electrosynthesis. It discusses innovative strategies for catalyst design and the electrosynthesis of diverse organonitrogen compounds, including urea, oximes, amino acids, amides, and amines. Additionally, it outlines future opportunities for sustainable C–N bond
Haifei Liu, Wenbo Wei, Qi‐Long Zhu
wiley   +1 more source

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