Results 191 to 200 of about 3,636,916 (342)

Non‐canonical PKG1 regulation in cardiovascular health and disease

open access: yesBritish Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado   +6 more
wiley   +1 more source

Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link

open access: yesThe FEBS Journal, EarlyView.
Human RNase 7 is known to exert antimicrobial activity in epithelial tissues. Here, using SH‐SY5Y and U‐87 MG, neuroblastoma and glioblastoma cell lines, respectively, we found that RNase 7 enhances immune responses to LPS stimulation by reducing the expression of pro‐inflammatory cytokines, nitric oxide, and ROS.
Rosanna Culurciello   +9 more
wiley   +1 more source

The Effect of Chlorhexidine Mouthwash on Blood Pressure: A Systematic Review and Meta‐Analysis

open access: yesInternational Journal of Dental Hygiene, EarlyView.
ABSTRACT Aim This study evaluated the effect of rinsing with a chlorhexidine containing mouthwash (CHX‐MW) on blood pressure (BP), as compared to rinsing with a control MW or no MW, based on (randomised) controlled trials and observational studies in humans. PROSPERO CRD42020222495.
Lars S. J. Toonen   +5 more
wiley   +1 more source

Ammonia and nitrite oxidation in the Eastern Tropical North Pacific

open access: yes, 2015
Xuefeng Peng   +6 more
semanticscholar   +1 more source

First attempt at using a synthetic diet in short‐lived killifish, a vertebrate model of ageing

open access: yesJournal of Fish Biology, EarlyView.
Abstract Diet standardization of model organisms is crucial for experimental consistency and repeatability in laboratory research, yet laboratory fish often lack species‐specific, open‐formula standardized diets. This study aims to address this gap by testing the effect of macronutrient content on the performance of Nothobranchius furzeri, an ...
Jakub Žák, Milan Vrtílek
wiley   +1 more source

Flavobacterium oreochromis From Farmed Tambaqui (Colossoma macropomum): Insights Into Genetic, Phenotypic and Pathogenic Diversity

open access: yesJournal of Fish Diseases, EarlyView.
ABSTRACT Flavobacterium spp. are the etiological agents of columnaris disease. Although there is evidence that columnaris poses a significant threat to the farming of tambaqui (Colossoma macropomum), there remains a large gap in understanding the genetic and phenotypic diversities of columnaris‐causing bacteria (CCB).
Elcimara Cardoso Pereira   +8 more
wiley   +1 more source

Key metabolites secreted by Chlorella vulgaris alleviate salt stress in soybean seedlings

open access: yesJournal of Integrative Plant Biology, EarlyView.
Chlorella vulgaris secretes exosome‐derived linolenic acid and inosine, which alleviate salt stress and enhance salt tolerance in soybean seedlings by activating stress‐responsive signaling networks. ABSTRACT Soil salinization is a major abiotic stress factor that reduces soybean production.
Yunyi Shi   +6 more
wiley   +1 more source

Sorption Isotherm Curves in Dry Extruded Pet Foods: Evaluation and Comparison With the Drying Curve

open access: yesJournal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Sorption isotherms evaluate water exchange between food and environments with different water activities (aw), providing valuable information on physical changes and susceptibility of deterioration due to lipid oxidation and microbial growth.
Mayara Uana da Silva   +4 more
wiley   +1 more source

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