Results 231 to 240 of about 173,810 (326)

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic   +4 more
wiley   +1 more source

Dinuclear Rhodium(I)–N‐Heterocyclic Carbene Complexes as Alkyne Hydropyridonation Catalysts

open access: yesEuropean Journal of Inorganic Chemistry, EarlyView.
Catalyst Improvement by NHC tuning: A series of new RhI–NHC dinuclear complexes has been revealed as efficient alkyne hydropyridonation catalysts. 333053IMes complex displays the highest reactivity of the series, suggesting that a moderate steric demand combined with balanced σ‐donation facilitates precatalyst activation and substrate exchange.
Belinda Español‐Sánchez   +7 more
wiley   +1 more source

Ring Formation in Sesquiterpene Synthesis: Biomimetic vs. Non‐Biomimetic Strategies

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
A short review of cyclase enzyme‐mediated ring formation in sesquiterpene biosynthesis is presented as a prelude to six case studies examining the merits and demerits of biomimetic vs. non‐biomimetic strategies for carbocyclisation in the total synthesis of this iconic natural product class.
Bohan Lin, Chen Dai, Alan C. Spivey
wiley   +1 more source

C-Imidoylation of esters, sulfones, sulfoxides, amides and nitro compounds

open access: yesARKIVOC, 2007
Alan R. Katritzky   +2 more
doaj   +1 more source

Photochemical Amination of Thioethers Under Biphasic Flow Conditions

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
Biphasic reaction conditions for the iron‐catalyzed synthesis of sulfilimines and sulfoximines in continuous flow using 2,2,2‐trichloroethyl‐N‐mesyloxycarbamate (TrocNHOMs). A practical, continuous flow, biphasic photochemical amination of thioethers, employing N‐mesyloxycarbamates as nitrene precursors, is reported. Using UVA irradiation at 365 nm and
Calvine Lai, Hélène Lebel
wiley   +1 more source

Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten   +15 more
wiley   +1 more source

Home - About - Disclaimer - Privacy