Results 141 to 150 of about 106,125 (294)

Cofactor-free biocatalytic hydrogenation of nitro compounds for synthesis of amines

We report a new paradigm for chemoselective hydrogenation of nitro compounds to amines, under mild, aqueous conditions. Hydrogenase enzyme releases electrons from H2 to a carbon black support which facilitates nitro-group reduction. For 30 nitroarenes we
Georgia, Stonadge, Holly, Reeve, Daria, Sokolova, Tara, Lurshay, Jack, Rowbotham, Sarah, Cleary, Tim, Sudmeier, Kylie, Vincent   +7 more
core   +1 more source

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition. [PDF]

ACS Chem Biol, 2018
Ray S, Kreitler DF, Gulick AM, Murkin AS.   +3 more
europepmc   +1 more source

Exploration of structure–activity relationship of 2,4‐diaminopyrimidine derivatives as hematopoietic progenitor kinase 1 inhibitors

Bulletin of the Korean Chemical Society, EarlyView.
Targeting HPK1 is a promising strategy to restore T‐cell anti‐tumor immunity. We report the design and synthesis of novel 2,4‐diaminopyrimidine derivatives, focusing on systematic structure–activity relationship (SAR) analysis These findings identify key structural features for potent HPK1 inhibition, facilitating the discovery of next‐generation ...
Heechan Shin, Mi‐Ran Byun, Joon Seok Choi, Sujin Lee   +3 more
wiley   +1 more source

Vicarious Nucleophilic Substitution of Hydrogen: An Excellent Tool for Porphyrin Functionalization

SynOpen
Stanisław Ostrowski, Agnieszka Mikus
doaj   +1 more source

Nitro-Group π System Drives the Interaction of RRx-001 with Electrons in Solution. [PDF]

Chemistry
Sedmidubská B, Denisov S, Mostafavi M, Denifl S, Izadi F, Ončák M, Luxford TFM, Chvátil D, Pinkas J, Kočišek J.   +9 more
europepmc   +1 more source

Homologous tumor‐targeting biomimetic nanozyme for synergistic NIR‐II photothermal and chemodynamic therapy

BMEMat, EarlyView.
Studies reveal that a biomimetic nanoplatform based on a cancer cell membrane‐camouflaged Au‐MnOx nanozyme (Au‐MnOx@CCM) can achieve synergistic antitumor therapy by combining NIR‐II mediated PTT with enhanced CDT, offering a promising strategy for precise and efficient tumor therapy. Abstract The therapeutic potential of nanozyme‐mediated chemodynamic
Xiaonan Li, Siman Luo, Yucheng Zuo, Liheng Chen, Houjuan Zhu, Jing‐Yi Zhu, Wei Xue   +6 more
wiley   +1 more source

Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives

Chemistry – A European Journal, EarlyView.
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome, Péter P. Fehér, András Stirling, Csongor G. Németh, Tamás Hergert, György M. Keserű, Péter Ábrányi‐Balogh   +6 more
wiley   +1 more source

Nitrocyclopropanes as Valuable Building Blocks in Organic Synthesis and Biology: Exploring the Origin of the Nitro Group. [PDF]

Chemistry
Chaidali AG, Terzidis MA, Lykakis IN.
europepmc   +1 more source

Piperidinodechlorination of chloro nitro naphthalenes. Further comparison between nitro-group and aza-group activation

, 1971
The importance of specific solvation (H bonding) in the nucleophilic reactions of N-heteroaromatic substrates has been stressed in recent studies and was suggested to be a major differential feature between aza- and nitro-group activation, on the ...
G. Illuminati, SPERANZA, Maurizio, G. Sleiter   +2 more
core