Nitropyridines as 2π-Partners in 1,3-Dipolar Cycloadditions with N-Methyl Azomethine Ylide: An Easy Access to Condensed Pyrrolines [PDF]
Molecules, 2021 1,3-Dipolar cycloaddition reactions of 2-substituted 5-R-3-nitropyridines and isomeric 3-R-5-nitropyridines with N-methyl azomethine ylide were studied. The effect of the substituent at positions 2 and 5 of the pyridine ring on the possibility of the [3 ...
Maxim A Bastrakov +2 more
exaly +4 more sources
Nucleophilic Functionalization of 2-R-3-Nitropyridines as a Versatile Approach to Novel Fluorescent Molecules [PDF]
Molecules, 2022 A number of new 2-methyl- and 2-arylvinyl-3-nitropyridines were synthesized and their reactions with thiols were studied. It was found that 3-NO2 tends to be selectively substituted under the action of sulfur nucleophiles in the presence of another ...
Mikhail E Minyaev +2 more
exaly +4 more sources
Nitropyridines in the Synthesis of Bioactive Molecules [PDF]
PharmaceuticalsPyridines are one of the most important and promising classes of N-heterocycles actively studied in modern organic and medicinal chemistry; in particular, pyridine is a privileged structural motif in drug design.
Alexey Starosotnikov, Maxim Bastrakov
doaj +4 more sources
Synthesis of Nitroaromatic Compounds via Three-Component Ring Transformations [PDF]
Molecules, 2021 1-Methyl-3,5-dinitro-2-pyridone serves as an excellent substrate for nucleophilic-type ring transformation because of the electron deficiency and presence of a good leaving group. In this review, we focus on the three-component ring transformation (TCRT)
Song Thi Le +2 more
doaj +2 more sources
Synthesis and Facile Dearomatization of Highly Electrophilic Nitroisoxazolo[4,3-b]pyridines [PDF]
Molecules, 2020 A number of novel 6-R-isoxazolo[4,3-b]pyridines were synthesized and their reactions with neutral C-nucleophiles (1,3-dicarbonyl compounds, π-excessive (het)arenes, dienes) were studied.
Maxim A. Bastrakov +4 more
doaj +2 more sources
CHEMICAL PROPERTIES AND APPLICATIONS OF NITROPYRIDINES
Siberian Journal of Life Sciences and Agriculture, 2023 Background. Pyridines are one of the most common heterocycles, the derivatives of which are widely used in pharmaceuticals, agrochemistry, and also in the production of new materials.
Evgeniya V. Ivanova +5 more
doaj +2 more sources
Mild and efficient synthesis and base-promoted rearrangement of novel isoxazolo[4,5-b]pyridines [PDF]
Beilstein Journal of Organic ChemistryAn efficient method for the synthesis of isoxazolo[4,5-b]pyridines has been developed on the basis of readily available 2-chloro-3-nitropyridines via the intramolecular nucleophilic substitution of the nitro group as a key step.
Vladislav V. Nikol’skiy +3 more
doaj +2 more sources
3-nitropyridine analogues as novel microtubule-targeting agents. [PDF]
PLoS ONEMicrotubule-targeting agents are an important class of anti-cancer drugs; their full potential is however not realized because of significant myelotoxicity and neurotoxicity.
Jean Herman +15 more
doaj +2 more sources
Nucleophilic dearomatization of 4-aza-6-nitrobenzofuroxan by CH acids in the synthesis of pharmacology-oriented compounds [PDF]
Beilstein Journal of Organic Chemistry, 2017 4-Aza-6-nitrobenzofuroxan (ANBF) reacts with 1,3-dicarbonyl compounds and other CH acids to give carbon-bonded 1,4-adducts – 1,4-dihydropyridines fused with furoxan ring.
Alexey M. Starosotnikov +5 more
doaj +2 more sources
2-(2,5-Dimethoxyphenyl)pyrrole-3-carbonitrile
Molbank, 2023 The Cadogan reaction of 2-aryl-3-nitropyridines leads to δ-carbolines. The title compound is a side product in this reaction, generated via a ring opening of a nitrene and cyclization. A crystal structure analysis gives an enormous unit cell.
Yannic Grimm +2 more
doaj +1 more source