Results 11 to 20 of about 154 (130)

METHODS OF NITROPYRIDINE SYNTHESIS

Siberian Journal of Life Sciences and Agriculture, 2021
Background. Pyridine derivatives are widely used in pharmaceuticals, agrochemistry, as well as in the production of new materials. The pyridine and piperidine rings are the main structural fragments of numerous natural alkaloids with a wide spectrum of ...
Evgeniya V. Ivanova, Maria B. Nikishina, Loik G. Mukhtorov, Irina V. Shahkeldyan, Yuri M. Atroshchenko   +4 more
doaj   +2 more sources

Metal-Free, Chemoselective Reduction of Aromatic Nitro Compounds in Water at Room Temperature. [PDF]

ChemistryOpen
A metal‐free, rapid, and chemoselective nitro reduction of aromatic compounds is developed using tetrahydroxydiboron as reducing agent and 4,4′‐bipyridine as organocatalyst. This green method provides an efficient entry to aromatic amines with high functional group tolerance in excellent yields under mild conditions using water as solvent. A metal‐free,
Batzaki M, Heugebaert TSA, Stevens CV.
europepmc   +2 more sources

Alkylation of Nitropyridines via Vicarious Nucleophilic Substitution. [PDF]

Org Lett, 2022
Electrophilic nitropyridines react with sulfonyl-stabilized carbanions to give products of C-H alkylation via vicarious nucleophilic substitution. The process consists of formation of the Meisenheimer-type adduct followed by base-induced β-elimination of the sulfinic acid (e.g., PhSO2H).
Antoniak D, Barbasiewicz M.
europepmc   +4 more sources

N-(6-Chloro-3-nitropyridin-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-amine

Molbank, 2021
Here we describe the synthesis of N-(6-chloro-3-nitropyridin-2-yl)5-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-amine via a three-step procedure including a Buchwald–Hartwig arylamination with benzophenone imine and a highly regioselective nucleophilic ...
Valentin Wydra, Stefan Gerstenecker, Dieter Schollmeyer, Stanislav Andreev, Teodor Dimitrov, Ricardo Augusto Massarico Serafim, Stefan Laufer, Matthias Gehringer   +7 more
doaj   +1 more source

Nitropyridines: Synthesis and reactions [PDF]

Pure and Applied Chemistry, 2003
Reaction of pyridine and substituted pyridines with N2O5 in an organic solvent gives the N-nitropyridinium ion. When this is reacted with SO2/HSO3– in water, 3-nitropyridine is obtained (77 % yield). With substituted pyridines, the method gives good yields for 4-substituted and moderate yields for 3-substituted pyridines.
openaire   +1 more source

Facile One-pot Protocol of Derivatization Nitropyridines: Access to 3-Acetamidopyridin-2-yl 4-methylbenzenesulfonate Derivatives

Heterocyclic Communications, 2019
This paper discloses an efficient one-pot protocol to convert easily accessible 3-nitropyridines to 3-acetamidopyridin-2-yl 4-methylbenzenesulfonate derivatives which are core structures of many pharmaceutical molecules.
Lin Ling, Chen Xiaoguang, Zhao Junhao, Lin Suitao, Ma Guojian, Liao Xiaojian, Feng Pengju   +6 more
doaj   +1 more source

Effect of pork carnosine level on lipid and protein oxidation markers during in vitro co‐digestion in a Mediterranean meal model

Journal of the Science of Food and Agriculture, Volume 106, Issue 7, Page 4008-4016, May 2026.
Abstract BACKGROUND This study assessed the effects of dietary carnosine during the in vitro digestion of a healthy meal model based on the Mediterranean diet, comprising lean pork enriched with two levels of carnosine, whole grain bread, tomato, onion, and olive oil.
Yi Yao Li, Varoujan Yaylayan, Marie‐France Palin, Tania M. Ngapo, Simon Cliche, Fleur Gagnon, Claude Gariépy   +6 more
wiley   +1 more source

A Genetically Encoded Homocysteine Precursor to Probe Protein Active Sites and to Addict Escherichia coli to a Noncanonical Amino Acid Directly Involved in Catalysis

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
A new genetically encoded amino acid is chemically converted into homocysteine (Hcy) under mild conditions to probe and to activate protein active sites. Surprisingly, Hcy can replace cysteine or serine residues in several enzymes. Its potential for a widespread use in proteins is further underlined by rendering Escherichia coli dependent on Hcy ...
Clara Dunker, Henning D. Mootz
wiley   +2 more sources

Multiple Dimerization Modes in Thiocarboxylate Paddlewheel Complexes: A Comprehensive View of Energy Landscapes from DFT Calculations and Statistics

Chemistry – A European Journal, Volume 32, Issue 15, 22 April 2026.
Staggered, square, and heavily bent dimers occur in the five known solvatomorphs of paddlewheel (PW) complex [PtVO(SOCPh)4]. These and other structural motifs are well within energetic reach due to the shallow potential energy surface that guides dimerization and are included in a revised classification of available structural data on heterobimetallic ...
Olga Mironova, Giacomo Bellini, Alessio Nicolini, Andrea Cornia   +3 more
wiley   +1 more source

Molecular Rotors as Reactivity Probes: Predicting Electrophilicity from the Speed of Rotation

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
A new empirical parameter, ERB, quantifies electrophilicity from rotational barriers of N‐phenylimide molecular rotors. ERB predicts reactivity trends in Michael additions, SN2, SNAr, Pd‐oxidative addition, and Sonogashira reactions by capturing both attractive and repulsive transition state interactions.
Hao Liu, Xiaolong Huang, Binzhou Lin, Harrison M. Scott, Ishwor Karki, Erik C. Vik, Perry J. Pellechia, Ken D. Shimizu   +7 more
wiley   +2 more sources