Results 21 to 30 of about 154 (130)
Advanced Science, Volume 13, Issue 9, 13 February 2026.The in situ mass spectrometric identification of the electrogenerated benzylic and phenylic carbocations, whose half‐lives in bulk solutions are on the nanosecond scale, is achieved by taking advantage of the unique stabilization effect of the electrosprayed microdroplets.
Guo‐Shan Zhu, Ren‐Jie Hui, Jun Hu
wiley +1 more source
Archiv der Pharmazie, Volume 359, Issue 1, January 2026.Focusing on the discovery of new therapeutics for childhood cancer, novel quinoline derivatives were synthesized and demonstrated activity against Ewing sarcoma. A target search was performed against a panel of kinases, and the compounds showed selectivity for the NAK family, mainly GAK, which was confirmed by enzyme kinetic assays.
Caroline de Bem Gentz +17 more
wiley +1 more source
ChemistryEurope, Volume 4, Issue 1, January 2026.Three novel Ln(III) complexes for efficient, site‐specific cysteine labeling under mild aqueous conditions are reported. A kinetic study reveals how subtle changes to the reactive pendant arm tune tagging rates, with Tb.QuNO achieving >95% cysteine labeling in 10 min.
Lydia Topping +8 more
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ChemMedChem, Volume 21, Issue 1, January 2026.Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri +14 more
wiley +1 more source
Journal of Chemistry, Volume 2026, Issue 1, 2026.This review aims to summarize recent developments (2020–2025) in the use of Suzuki–Miyaura cross‐coupling reactions for the synthesis and functionalization of pyridine, indole, and quinoline derivatives—three classes of heterocycles known for their wide‐ranging biological and pharmacological significance.
Shreyas Krishna K. +4 more
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Dearomative Nucleophilic Addition of Lithium Enolates to Electron‐Poor Indoles
ChemPhysChem, Volume 26, Issue 23, November 28, 2025.Electrophilic electron‐depleted indoles undergo 1,4‐addition to afford the dearomatized products, with complete diastereoselectivity, after smooth hydrolysis. While 3‐nitroindoles readily furnish the corresponding nitroindolines, α‐ketoamide indoles show a more complex reactivity, undergoing either 1,2‐ or 1,4‐addition, depending on the steric ...
Mélanie Roseau +4 more
wiley +1 more source
Advanced Materials, Volume 37, Issue 44, November 6, 2025.Pt‐impy and Pt‐Me‐impy exhibit external quantum efficiencies of 24.5% and 27.4% at the 3 wt.% doping concentration, respectively. In particular, Pt‐impy and Pt‐Me‐impy doped blue PhOLEDs optimized for stability demonstrate a device lifetime of up to 95% of the initial luminance of 543 and 228 h at 1000 cd m−2, which has never been achieved in the blue ...
Kiun Cheong +12 more
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Hybrid Diagonal Approximation in Time‐Dependent Auxiliary Density Functional Theory
Journal of Computational Chemistry, Volume 46, Issue 23, September 5, 2025.Our work demonstrates that time‐dependent auxiliary density functional theory (TD‐ADFT) in combination with the hybrid diagonal approximation (HDA) for global and range‐separated hybrid functionals is a promising approach for low‐order scaling electronic excitation energy calculations.
Kevin O. Pérez‐Becerra +4 more
wiley +1 more source
Free‐Standing Supramolecular Pyridine N‐Oxide‐Silver(I) Metallogels
Advanced Materials, Volume 37, Issue 37, September 18, 2025.A comprehensive analysis of pyridine N‐oxide‐silver(I) trifluoroacetate complexes reveals remarkable mechanical strengths that enable the creation of free‐standing objects with shape control, reaching dimensions of up to centimeters and shedding new insights into the gelation mechanisms.
Rakesh Puttreddy +8 more
wiley +1 more source
Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.Die Bioreversible Arginin‐Modifikation aminhaltiger Proteinreste (BioRAM) ermöglicht eine serumkompatible, leicht zugängliche und effiziente Einschleusung nativer Proteine in lebende Zellen. In Kombination mit zellpenetrierenden Peptid‐Additiven führt BioRAM zu nanomolarer intrazellulären RNase‐A‐Aktivität und erlaubt so den zellulären Transport ...
Jonathan Franke +3 more
wiley +1 more source