Results 111 to 120 of about 2,041 (198)

P38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity [PDF]

, 2014
Background Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease.
Ming, Xiu-Fen, Montani, Jean-Pierre, Rajapakse, Angana G., Yang, Zhihong, Yu, Yi   +4 more
core   +2 more sources

Divergent cardiac and renal effects of miR-181c-5p inhibition in a rodent heart failure model

Frontiers in Cardiovascular Medicine
AimsMiR-181c-5p overexpression associates with heart failure (HF) and cardiac damage, but the underlying pathophysiology remains unclear. This study investigated the effect of miR-181c-5p inhibition on cardiac function and fibrosis in a rodent model of ...
Jente R. A. Boen, Jente R. A. Boen, Andreas B. Gevaert, Andreas B. Gevaert, Amélie Dendooven, Amélie Dendooven, Dustin Krüger, Michiel Tubeeckx, Jens Van Fraeyenhove, Tine Bruyns, Vincent F. M. Segers, Vincent F. M. Segers, Emeline M. Van Craenenbroeck, Emeline M. Van Craenenbroeck   +13 more
doaj   +1 more source

Modulatory effects of taurine on jejunal contractility

Brazilian Journal of Medical and Biological Research, 2014
Taurine (2-aminoethanesulfonic acid) is widely distributed in animal tissues and has diverse pharmacological effects. However, the role of taurine in modulating smooth muscle contractility is still controversial.
Q.Y. Yao, D.P. Chen, D.M. Ye, Y.P. Diao, Y. Lin   +4 more
doaj   +1 more source

DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol [PDF]

, 2015
2-Methoxyestradiol (2-ME) is a physiological metabolite of 17β-estradiol. At pharmacological concentrations, 2-ME inhibits colon, breast and lung cancer in tumor models.
CAPPELLO, Francesco, Daca, A., Gorska, M., Gorzynik, Monika, Kuban Jankowska, A., Lewinska, A., MARINO GAMMAZZA, Antonella, Rzeszutek, I., Wnuk, M., Wozniak, M., Zmijewski, M.   +10 more
core   +2 more sources

Mediators Involved in Decreasing Peripheral Vascular Resistance With Carbachol in the Rat Hind Limb Perfusion Model

Journal of Pharmacological Sciences, 2005
We examined the involvement of nitric oxide (NO) and/or endothelium-derived hyperpolarizing factor (EDHF) in decreasing peripheral vascular resistance in the rat hind limb perfusion model and analyzed the identity of EDHF in this model.
Renzo Y. Loyaga-Rendon, Shuichi Sakamoto, Takeshi Aso, Keiko Iwasaki-Kurashige, Ryoko Takahashi, Hiroshi Azuma   +5 more
doaj   +1 more source

Bradykinin -induced vasodilatation : Role of age, ACE1-inhibitory peptide, mas- and bradykinin receptors [PDF]

, 2016
Bradykinin exerts its vascular actions via two types of receptors, the non-constitutively expressed bradykinin receptor type 1 (BR1) and the constitutive type 2 receptor (BR2).
Korpela, R., Siltari, Aino, Vapaatalo, H.   +2 more
core   +1 more source

Dioscorea prehensilis Ameliorates the Features of Preeclampsia in L-NG-Nitroarginine Methyl Ester (L-NAME) Preeclamptic Model [PDF]

, 2018
Iyabo Adebisi, Shaibu Oricha Bello, Constance Egondu Shehu, Musa Abdullahi, Chinenye J. Ugwah‐Oguejiofor, Nnaemeka Ndodo, Mohammed Umar   +6 more
openalex   +1 more source

Testosterone Antagonizes Doxorubicin‐Induced Senescence of Cardiomyocytes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundChronic cardiotoxicity is less common in male than in female patients receiving doxorubicin and other anthracyclines at puberty and adolescence.
Paola Altieri, Chiara Barisione, Edoardo Lazzarini, Anna Garuti, Gian Paolo Bezante, Marco Canepa, Paolo Spallarossa, Carlo Gabriele Tocchetti, Sveva Bollini, Claudio Brunelli, Pietro Ameri   +10 more
doaj   +1 more source

Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways [PDF]

, 2016
This paper is a review on the types of antagonists and the signaling mechanism pathways that have been used to determine the mechanisms of action employed for vasodilation by test compounds.
Ahmad, Mariam, Asmawi, Mohd Zaini, Chu, Shan Tan, Mun, Fei Yam, Yean, Chun Loh, Yung, Sing Ch’ng   +5 more
core   +1 more source

Heterogeneity of endothelial dysfunction in hypertension [PDF]

, 2017
The endothelium may play a role as a target and mediator of hypertension. Due to its anatomical position, it is very exposed to mechanical forces; as a source of vasoactive material it may participate in increasing peripheral vascular resistance and in ...
Lüscher, T. F.
core