Results 171 to 180 of about 2,041 (198)
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Response of Spinal Cord Blood Flow to the Nitric Oxide Inhibitor Nitroarginine
Neurosurgery, 1996The extent to which nitric oxide (NO) is involved in the modulation of spinal cord blood flow (SCBF) in the uninjured and injured cord is unknown. To elucidate these questions, the following experiments in anesthetized rats were conducted.Because NO is an unstable free radical with a half-life of seconds, its role can be understood through the study of
P W, Hitchon +4 more
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Microalbuminuria in Rats Treated with D-Nitroarginine Methyl Ether
Bulletin of Experimental Biology and MedicineMicroalbuminuria is an early symptom and prognostic marker of the progression of renal pathology. The analysis of the role of anionic components of the renal glomeruli in the albumin retention and the development of a model of minimal changes in the glomerular filter leading to the appearance of microalbuminuria are relevant.
E V, Balbotkina +3 more
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Journal of Cardiovascular Pharmacology, 1991
The interaction of endothelin-1 (ET-1), a novel vasoconstrictor peptide synthesized according to the encoded amino acid sequence, with L-NG-nitroarginine (NOARG), an L-arginine-reversible inhibitor of endothelium-derived relaxing factor (EDRF) on adrenergic receptors, was investigated. Male Sprague-Dawley rats were used in this study.
Y, Tabuchi +3 more
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The interaction of endothelin-1 (ET-1), a novel vasoconstrictor peptide synthesized according to the encoded amino acid sequence, with L-NG-nitroarginine (NOARG), an L-arginine-reversible inhibitor of endothelium-derived relaxing factor (EDRF) on adrenergic receptors, was investigated. Male Sprague-Dawley rats were used in this study.
Y, Tabuchi +3 more
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Conducted Arteriolar Dilations Persist in the Presence of Nitroarginine
Journal of Cardiovascular Pharmacology, 1997At least two mechanisms of arterial dilations are induced by the application of muscarinic agonists. One is caused by nitric oxide, and the second is the result of the release of an endothelium-dependent hyperpolarizing factor (EDHF) that has yet to be clearly defined. This study was performed to determine whether two modes of dilation also are present
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CHANGES OF ENDOTHELIAL FUNCTIONS IN THE CORONARY ARTERY AFTER CHRONIC NITROARGININE FEEDING
Clinical and Experimental Pharmacology and Physiology, 1995Summary1. The effects of chronic NG‐nitro‐L‐arginine (LNA) feeding on the endothelial function in isolated coronary arteries from stroke‐prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar‐Kyoto (WKY) rats were studied.2. A diet containing LNA (0.02%) was given to male SHRSP and WKY at 6 weeks of age and the coronary arteries were ...
N, Kajimoto, H, Ogawa, A, Suzuki
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Renal Effects of the Nitric Oxide Synthase Inhibitor, L-NG-Nitroarginine, in Dogs
American Journal of Hypertension, 1992L-NG-Nitroarginine (LNNA), an analog of L-arginine, was infused into the renal artery of anesthetized dogs to assess the contribution of nitric oxide production in the regulation of renal hemodynamics and urine formation. Following intrarenal arterial infusion of LNNA (15 micrograms/kg/min) for 25 min, renal blood flow (RBF) gradually decreased and ...
T, Yukimura +5 more
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Nanomolar NG-nitroarginine inhibits NMDA-induced cyclic GMP formation in rat cerebellum
European Journal of Pharmacology, 1990The very large increases in cyclic GMP levels that occur in cerebellar slices in response to N-methyl-D-aspartate (NMDA) receptor agonists result from the synthesis of the guanylate cyclase activator, nitric oxide, from L-arginine. We show that an arginine analogue, L-NG-nitroarginine, inhibits the cyclic GMP response to NMDA in an arginine-sensitive ...
S J, East, J, Garthwaite
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Quantitative Bestimmung von Nitroarginin in synthetischen Polypeptiden
Helvetica Chimica Acta, 1962AbstractA spectrochemical method for the assay of ω‐nitroarginine in synthetic peptides is described. It is based on the strong difference in absorption of the nitroarginyl residue in the two solvents dimethylformamide (DMF)/0,2N HCl (1:1; v/v) and anhydrous trifluoroacetic acid (TFA).
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Nitroarginine Reduces Infarction After Middle Cerebral Artery Occlusion in Rats
1994Neuronal production of nitric oxide (·NO) provides a common link between two seemingly independent mechanisms of brain injury—excitatory neurotransmitters and oxygen radicals. The connection results from the recent demonstration that glutamate stimulates neurons to produce nitric oxide (Garthwaite et al. 1988). Neurons produce nitric oxide by oxidizing
J. Chen +3 more
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Endothelin‐1 and relaxation of the rat aorta during pregnancy in nitroarginine‐induced hypertension
Fundamental & Clinical Pharmacology, 1999Abstract— In pregnant rats during hypertension induced by NO synthase inhibition, endothelin (ET) plasma levels are increased as in some preeclamptic women. Previously, the enhanced vasodepressor effect of endothelin‐1 (ET‐1) has been observed in this model, thus we decided to study the relaxation induced by ET‐I on the aorta.
A M, Dieye, B, Van Overloop, A, Gairard
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