Results 21 to 30 of about 2,041 (198)

Effects of oxidative stress on liver, brain and spinal cord of rats using L-NAME and treated with hydroxyurea. A model of sickle cell complication [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose: To analyze the serum levels of nitric oxide and correlate them with the levels of thiobarbituric acid reactive substances (TBARS) in liver, brain and spinal cord of animals using L-NAME and treated with hydroxyurea.
Abilio Torres dos Santos Neto, Iandara Schettert Silva, Maria Lucia Ivo, Camila Tozaki Rodrigues, Eduardo Benedetti Parisotto, Rondon Tosta Ramalho, Geanlucas Mendes Monteiro   +6 more
doaj   +1 more source

Role of Endothelial Nitric Oxide Synthase in Isoflurane Conditioning‐Induced Neurovascular Protection in Subarachnoid Hemorrhage

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Delayed cerebral ischemia remains a common and profound risk factor for poor outcome after subarachnoid hemorrhage (SAH). The aim of our current study is to define the role of endothelial nitric oxide synthase (eNOS) in isoflurane conditioning‐
Umeshkumar Athiraman, Keshav Jayaraman, Meizi Liu, Tusar Giri, Jane Yuan, Gregory J. Zipfel   +5 more
doaj   +1 more source

Effects of L-arginine and L-NAME on ischemia-reperfusion in rat liver [PDF]

Acta Cirúrgica Brasileira, 2015
PURPOSE: To evaluated the effects of L-arginine (a NO donor) and L-NAME (Nw-nitro-L-arginine methyl ester - a NOS inhibitor) on ischemia-reperfusion in rat livers.METHODS: One hundred fifty two male Wistar rats were divided into four groups: control ...
Márcio Luís Lucas, Cláudia Ramos Rhoden, Ernani Luís Rhoden, Cláudio Galeano Zettler, Angelo Alves de Mattos   +4 more
doaj   +1 more source

Novel enhancers of guanylyl cyclase‐A activity acting via allosteric modulation

British Journal of Pharmacology, Volume 180, Issue 24, Page 3254-3270, December 2023., 2023
Abstract Background and Purpose Guanylyl cyclase‐A (GC‐A), activated by endogenous atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), plays an important role in the regulation of cardiovascular and renal homeostasis and is an attractive drug target. Even though small molecule modulators allow oral administration and longer half‐life,
Henriette Andresen, Cristina Pérez‐Ternero, Jerid Robinson, Deborah M. Dickey, Adrian J. Hobbs, Lincoln R. Potter, Finn Olav Levy, Alessandro Cataliotti, Lise Román Moltzau   +8 more
wiley   +1 more source

The Possible Anti-nociceptive Effect of Troxerutin and Neural Interactions Using Formalin and Writhing Tests in Mice [PDF]

Avicenna Journal of Medical Biochemistry, 2023
Background: Previous reports suggest flavonoids as potent analgesic compounds. Objectives: Based on these observations, the present study investigated the anti-nociceptive action of troxerutin and neural interactions with opioidergic, serotoninergic ...
Farima Jafari-Tirabadi, Shahin Hassanpour, Ahmad Asghari   +2 more
doaj   +1 more source

Signaling from blood vessels to CNS axons through nitric oxide [PDF]

, 2006
Brain function is usually perceived as being performed by neurons with the support of glial cells, the network of blood vessels situated nearby serving simply to provide nutrient and to dispose of metabolic waste.
Bartus, K, Dooldeniya, C, Garthwaite, G, Garthwaite, J, Goodwin, D, Kollb-Sielecka, M, Malcolm, D   +6 more
core   +1 more source

CNS sites controlling the gastric pyloric sphincter: Neuroanatomical and functional study in the rat

Journal of Comparative Neurology, Volume 531, Issue 15, Page 1562-1581, October 2023., 2023
The dorsal motor nucleus of the vagus (DMV) of the brainstem is a crucial region that modulates the activity of gastric function. The pyloric sphincter at the gastroduodenal junction, which regulates the flow of partially digested food from the stomach, is mediated by the nucleus in a site‐specific manner.
Janell Richardson, Ghazaul Dezfuli, Allen W. Mangel, Richard A. Gillis, Stefano Vicini, Niaz Sahibzada   +5 more
wiley   +1 more source

Influence of hyperhomocysteinemia on the cellular redox state - Impact on homocysteine-induced endothelial dysfunction [PDF]

, 2003
Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteines deleterious effects on the vasculature.
Adachi T, Andersson A, Bagi Z, Bellamy MF, Chambers JC, Chambers JC, Chao CL, Flohé L, Forgione MA, Guttormsen AB, Huang R-FS, Kanani PM, Karlsson K, Lang D, Lentz SR, Mansoor MA, Mansoor MA, Mansoor MA, Mansoor MA, O'Donnell VB, Outinen PA, Pritchard, Rubbo H, Tawakol A, Ungvari Z, Weiss N, Wilcken DE, Woo KS, Zhang F, Zhang X   +29 more
core   +1 more source

Polymer nanomaterials for use as adjuvant surgical tools

WIREs Nanomedicine and Nanobiotechnology, Volume 15, Issue 4, July/August 2023., 2023
Current materials deployed in surgery as wound dressings, tissue adhesives, surgical sealants, hemostats, and postoperative adhesion barriers are prone to failure due to a nonoptimized balance of cohesive and adhesive strength. Abstract Materials employed in the treatment of conditions encountered in surgical and clinical practice frequently face ...
Metecan Erdi, Anthony Sandler, Peter Kofinas   +2 more
wiley   +1 more source

Characterization of Endothelium-Dependent Relaxation in the Saphenous Artery and Its Caudal Branches in Young and Old Adult Sprague Dawley Rats

Biomolecules, 2022
Ageing is associated with reduced endothelium-derived nitric oxide (NO) production in the femoral artery of Sprague Dawley (SD) rats. In the current study, we examined endothelium-dependent relaxation (EDR) in the saphenous artery and its caudal branches.
Andrea N. Wang, Graham M. Fraser, John J. McGuire   +2 more
doaj   +1 more source