Results 31 to 40 of about 2,041 (198)
Exercise training and losartan improve endothelial function in heart failure rats by different mechanisms [PDF]
, 2013 Objectives. To investigate the mechanisms of losartan- and exercise training-induced improvements on endothelial dysfunction in heart failure. Design. Sprague-Dawley rats subjected to left coronary artery ligation inducing myocardial infarction and heart
Crozier I +5 more
core +1 more source
Journal of Extracellular Vesicles, Volume 12, Issue 5, May 2023., 2023 Am produced EVs in the GI tract. AmEVs can cross the intestinal barrier and reach the placenta in dams. AmEVs can interact with trophoblasts to improve trophoblast proliferation, migration and invasion by activating the EGFR‐PI3K‐AKT signalling pathway, which further promotes SpA remodelling. The graphical abstract was created with BioRender.com.
Yun Chen +15 more
wiley +1 more source
Journal of Lipid Research, 1999 The vascular effects of arachidonic acid (AA) were addressed in the rat perfused heart in terms of metabolic pathways and effector mechanisms. Under basal perfusion pressure, AA elicited dilator responses. However, in hearts treated with nitroarginine to
Y. Qiu, J. Quilley
doaj +1 more source
Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus. [PDF]
, 2016 Nitric oxide (NO) has long been implicated in the generation of long-term potentiation (LTP) and other types of synaptic plasticity, a role for which the intimate coupling between NMDA receptors (NMDARs) and the neuronal isoform of NO synthase (nNOS) is ...
Garthwaite, J, Pigott, BM
core +1 more source
Journal of Cell Communication and Signaling, Volume 17, Issue 1, Page 151-165, March 2023., 2023 Graphical abstract Xing et al. (2022) investigated the critical role of MIG6 in vascular permeability. MIG6 deficiency promotes VEGFA‐induced vascular permeability via activation of PLCγ1‐Ca2+‐eNOS signaling and perturbation of the balance in RAC1/RHOA activation, resulting in endothelial barrier disruption.
Liying Xing +12 more
wiley +1 more source
Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain [PDF]
, 2009 In low nanomolar concentrations, NO (nitric oxide) functions as a transmitter in brain and other tissues, whereas near-micromolar NO concentrations are associated with toxicity and cell death.
Garthwaite, J., Hall, C.N., Keynes, R.G.
core +3 more sources
Journal of Pharmacological Sciences, 2014 .: Septic shock and associated vascular hyporeactivity to vasoconstrictor agonists remain a major problem of critical care medicine. Here we report that glycyrrhetinic acid (GA), the active component of licorice, effectively restores vascular ...
Bernard Muller +3 more
doaj +1 more source
Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells [PDF]
, 2014 The anti-human immunodeficiency virus (HIV) drug efavirenz (EFV) alters mitochondrial function in cultured neurons and glial cells. Nitric oxide (NO) is a mediator of mitochondrial dysfunction associated with HIV central nervous system symptoms.
Alegre, Fernando +5 more
core +1 more source
l-2-Nitrimino-1,3-diazepane-4-carboxylic acid
Acta Crystallographica Section E, 2008 The cyclic form of l-nitroarginine, C6H10N4O4, crystallizes with two independent molecules in the asymmetric unit. According to the geometrical parameters, similar in both molecules, the structure corresponds to that of l-2-nitrimino-1,3-diazepane-4 ...
Harutyun A. Karapetyan
doaj +1 more source
Transplantation Reports, 2022 Background: The small intestine is one of the most sensitive organs to ischemia. L-arginine has been shown to reduce damage from ischemia and reperfusion injury.
Michele Finotti +11 more
doaj +1 more source