Results 51 to 60 of about 2,041 (198)

Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration

Neurobiology of Disease, 2003
The present study was designed to examine whether expression of iNOS was involved in LPS-induced neurodegeneration in rat substantia nigra (SN) and to study the role of NO in the loss of the SN dopaminergic neurons.
Toyoko Arimoto, Guoying Bing
doaj   +1 more source

Gallic Acid Attenuates Angiotensin II-Induced Hypertension and Vascular Dysfunction by Inhibiting the Degradation of Endothelial Nitric Oxide Synthase

Frontiers in Pharmacology, 2020
Hypertension is a major cause of heart attack and stroke. Our recent study revealed that gallic acid (GA) exerts protective effects on pressure overload-induced cardiac hypertrophy and dysfunction.
Xiao Yan, Qi-Yu Zhang, Yun-Long Zhang, Xiao Han, Shu-Bin Guo, Hui-Hua Li, Hui-Hua Li   +6 more
doaj   +1 more source

S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis. [PDF]

, 2017
Studies suggest that a low level of circulating human endothelial progenitor cells (EPCs) is a risk factor for ischemic injury and coronary artery disease (CAD). Consumption of S-allylcysteine (SAC) is known to prevent CAD.
Chao, Che-Yi, Chiang, En-Pei Isabel, Chiu, Shao-Chih, Rodriguez, Raymond L, Syu, Jia-Ning, Tang, Feng-Yao, Tsai, Shu-Yao, Yang, Mei-Due   +7 more
core   +1 more source

Alamandine and Its Receptor MrgD Pair Up to Join the Protective Arm of the Renin-Angiotensin System [PDF]

, 2019
Only a few years ago, alamandine was found to be a member of the protective arm of the renin-angiotensin system. It turned out to be an endogenous ligand of the G protein-coupled receptor MrgD.
Schleifenbaum, Johanna
core   +1 more source

Transfer hydrogenation; a convenient method for removal of some commonly used protecting groups in peptide synthesis [PDF]

, 1977
N-Benzyloxycarbonyl and benzyl ester groups in peptidescan be conveniently removed by transfer hydrogenation with cyclohexene and 10% palladium-carbon catalyst.
Anantharamaiah, G.M., Sivanandaiah, K.M.
core   +1 more source

Long-lasting endothelium-dependent relaxation of isolated arteries caused by an extract from the bark of Combretum leprosum

Einstein (São Paulo)
Objective To describe and to characterize the relaxing effect of an extract of the bark of Combretum leprosum on isolated arterial rings from different animals.Methods Rings (3 to 4mm) from rabbit, rat, or porcine arteries rings were suspended in an ...
Francisco das Chagas Alves Filho, Paulo Marques da Silva Cavalcanti, Rita de Cassia Aleixo Tostes Passaglia, Gustavo Ballejo   +3 more
doaj   +1 more source

Physalis angulata Leaf Ethanol Extract Reduces Oxidative Stress and Improves Endothelial Progenitor Cells in L-NAME-Induced Hypertensive Rats

Hayati Journal of Biosciences, 2022
This study aimed to evaluate the effects of ciplukan (Physalis angulata L.) leaf ethanol extract on L-NG-nitroarginine methyl ester (L-NAME)-induced hypertensive rats. We randomly divided twenty-five Wistar rats into five groups.
Dian Nugrahenny, Nur Permatasari, Setyawati Soeharto, Indriati Dwi Rahayu, Edwin Widodo, Karyono Mintaroem, Hidayat Sujuti, Retty Ratnawati, Elly Mayangsari, Dicky Faizal Irnandi, Lavina Sofia Ardani, Tika Ardhini Wardoyo, Nathania Bella Claresta, Nura Fattah Cantika Yoga, Adinda Chika Anindita, Niarti Ulan Sari Siarnu, Fardizia Putri Alia   +16 more
doaj   +1 more source

Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells [PDF]

, 2016
Expression of follicle-stimulation hormone receptor (FSHR) is confined to gonads and at low levels to some extragonadal tissues like human umbilical vein endothelial cells (HUVEC). FSH-FSHR signaling was shown to promote HUVEC angiogenesis and thereafter
Akerfelt, Malin, Chrusciel, Marcin, Doroszko, Milena, Frentsch, Marco, Huhtaniemi, Ilpo, Kero, Jukka, Li, Xiangdong, Nees, Matthias, Ponikwicka-Tyszko, Donata, Rahman, Nafis A., Stelmaszewska, Joanna, Wolczynski, Slawomir   +11 more
core   +1 more source

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. [PDF]

, 2008
Priapism, abnormally prolonged penile erection in the absence of sexual excitation, is associated with ischemia-mediated erectile tissue damage and subsequent erectile dysfunction.
Abbasi, Shahrzad, Blackburn, Michael R, Chunn, Janci L, Kellems, Rodney E, Mi, Tiejuan, Molina, Jose G, Uray, Karen, Weisbrodt, Norman W, Xia, Ling Wei, Xia, Yang, Zhang, Hong   +10 more
core   +2 more sources

7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures [PDF]

, 1995
7-Nitro indazole (25–100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system
Dzoljic, E. (Eleonora), Leeuwen, R. (Redmer) van, Vries, R.R.P. (René) de   +2 more
core   +1 more source