Results 61 to 70 of about 2,041 (198)

Participation of NO in the vasodilatory action of isoespintanol

Vitae, 2019
Background: accumulating evidence suggests that natural compounds and specifically monoterpenes exert a vasodilator action. Objetive: to investigate the vascular effects of isoespintanol (2-isopropil-3,6- dimetoxi-5-metilfenol, ISO) monoterpene isolated ...
Gustavo J. RINALDI, Benjamín ROJANO, Guillermo SCHINELLA, Susana M. MOSCA   +3 more
doaj   +1 more source

Compromised Cortical-Hippocampal Network Function From Transient Hypertension: Linking Mid-Life Hypertension to Late Life Dementia Risk

Frontiers in Neuroscience, 2022
Mid-life hypertension is a major risk factor for developing dementia later in life. While anti-hypertensive drugs restore normotension, dementia risk remains above baseline suggesting that brain damage sustained during transient hypertension is ...
Aaron Y. Lai, Paolo Bazzigaluppi, Christopher D. Morrone, Mary E. Hill, Bojana Stefanovic, Bojana Stefanovic, JoAnne McLaurin, JoAnne McLaurin   +7 more
doaj   +1 more source

p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels. [PDF]

, 2016
BACKGROUND: The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs.
Brooks, G, Fan, LM, Ghazaly, MM, Howlin, B, Krönke, M, Li, J-M, Meijles, DN   +6 more
core   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Tumor Necrosis Factor - Related Apoptosis-Inducing Ligand (TRAIL) promotes angiogenesis and ischemia- induced neovascularization via NADPH Oxidase 4 (NOX4) and Nitric Oxide - dependent mechanisms [PDF]

, 2015
Background — Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has the ability to inhibit angiogenesis by inducing endothelial cell death, as well as being able to promote pro- angiogenic activity in vitro.
Azahri, N, Cartland, S, Di Bartolo, B, Gentile, C, Griffith, T, Kavurma, M, Prado-Lourenco, L, Ravindran, J, Thai, T, Thomas, S, Yeung, A   +10 more
core   +2 more sources

Glutamine enhances endothelial cell survival and vasodilation by increasing glutathione to reduce oxidative stress

Physiological Reports, Volume 14, Issue 2, January 2026.
Abstract Cardiovascular disease is exacerbated by diabetes through hyperglycemia‐induced endothelial dysfunction, which arises from oxidative stress. Glutamine is postulated to decrease oxidative stress; however, its effect on endothelial dysfunction in hyperglycemia is unknown.
Marzyeh Kheradmand, Gurneet Sangha, Claire M. Sissons, Michael Sun, Xinyao Zhou, Lauren V. Smith, Meagan Bauer, Chengpeng Chen, Alisa Morss Clyne   +8 more
wiley   +1 more source

GLP‐2 and GIP acutely increase superior mesenteric artery blood flow in male rats, and the effect is independent of nitric oxide and vasoactive intestinal peptide

Physiological Reports, Volume 13, Issue 23, December 2025.
GLP‐2 and GIP acutely increase superior mesenteric artery blood flow in male rats, and the effect is independent of nitric oxide and vasoactive intestinal peptide. Abstract Following a meal, splanchnic blood flow increases. This is important for nutrient absorption and is regulated by the enteric nervous system and gastrointestinal (GI) hormones ...
Katrine D. Galsgaard, Bolette Hartmann, Mette M. Rosenkilde, Jens J. Holst, Lærke S. Gasbjerg, Charlotte M. Sørensen   +5 more
wiley   +1 more source

Role of HO/CO in the Control of Peripheral Circulation in Humans

International Journal of Hypertension, 2012
Experimental studies show that the heme oxygenase/carbon monoxide system (HO/CO) plays an important role in the homeostasis of circulation and in the pathophysiology of hypertension.
David Sacerdoti, Despina Mania, Paola Pesce, Silvia Gaiani, Angelo Gatta, Massimo Bolognesi   +5 more
doaj   +1 more source

Change in the Interstitial Cells of Cajal and nNOS Positive Neuronal Cells with Aging in the Stomach of F344 Rats. [PDF]

PLoS ONE, 2017
The gastric accommodation reflex is an important mechanism in gastric physiology. However, the aging-associated structural and functional changes in gastric relaxation have not yet been established.
Yong Hwan Kwon, Nayoung Kim, Ryoung Hee Nam, Ji Hyun Park, Sun Min Lee, Sung Kook Kim, Hye Seung Lee, Yong Sung Kim, Dong Ho Lee   +8 more
doaj   +1 more source

Disrupted circadian rhythms and opioid‐mediated adverse effects: Bidirectional relationship and putative mechanisms

Journal of Neuroendocrinology, Volume 37, Issue 9, September 2025.
Abstract Recent studies have shown a link between disrupted circadian rhythms and the development of chronic opioid‐induced negative effects. Both animal and human studies show a significant bidirectional relationship between the circadian system and opioid effects.
Nasrin Mehranfard, Maedeh Ghasemi, Ehsan Saboory   +2 more
wiley   +1 more source