Results 81 to 90 of about 2,041 (198)
Physiological Reports, Volume 12, Issue 18, September 2024.The vasoactive response to the nonsteroidal mineralocorticoid receptor antagonist (MRA) finerenone was tested ex vivo in arteries of human visceral adipose tissue (VAT). Finerenone elicited endothelium‐independent vasorelaxation in arteries precontracted with different vasoconstrictors; the steroidal MRA potassium canrenoate, by contrast, did not relax
Francesca Schinzari +5 more
wiley +1 more source
Increasing the fungicidal action of Amphotericin B by inhibiting the Nitric Oxide-Dependent tolerance pathway [PDF]
, 2017 Amphotericin B (AmB) induces oxidative and nitrosative stresses, characterized by production of reactive oxygen and nitrogen species, in fungi. Yet, how these toxic species contribute to AmB-induced fungal cell death is unclear.
Cammue, Bruno P. A. +10 more
core +3 more sources
Neurourology and Urodynamics, Volume 43, Issue 6, Page 1253-1260, August 2024.Abstract Aims The aim of a preliminary session of the International Continence on Incontinence—Research Society (ICI‐RS) was to provide a forum for an international group of experimental scientists, who are members of ICI‐RS, to explain their on‐going work to fellow laboratory scientists, to obtain feedback about future directions and discuss potential
Christopher Fry
wiley +1 more source
Thymoquinone causes endothelium-dependent augmentation of contraction depending on activation of soluble guanylyl cyclase in isolated arteries [PDF]
, 2013 Poster - Vascular Responsiveness: no. 4/7INTRODUCTION: Experiments were designed to determine the effects of thymoquinone, an alkaloid with in vivo vasodilator properties, in isolated arteries.
Alkharfy, K +6 more
core
Oliveria decumbens, a Long‐Neglected Plant with Promising Phytochemical and Biological Properties
Chemistry &Biodiversity, Volume 21, Issue 7, July 2024.Abstract Oliveria decumbens is a folkloric medicinal plant belonging to the Apiaceae family, traditionally utilized to treat various diseases like gastrointestinal disorders, fever, and wounds. This review aims to provide a comprehensive overview of the plant‘s phytochemical composition and biological properties, with potential implications for various
Anahita Boveiri Dehsheikh +4 more
wiley +1 more source
Mechanisms involved in the remyelinating effect of sildenafil [PDF]
, 2018 Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease.
Díaz-Lucena, Daniela +5 more
core +1 more source
Advanced Science, Volume 11, Issue 21, June 5, 2024.The down‐regulation of THBS1 can destabilize TAK1 via NEDD4‐mediated, K48‐linked TAK1 ubiquitination, resulting in the activation of the necroptosis and DAMPs release in trophoblast cells, thus participating in the pathogenesis of PE. Abstract Preeclampsia (PE) is considered as a disease of placental origin. However, the specific mechanism of placental
Haoyue Hu +15 more
wiley +1 more source
Protective effect of picroside II on myocardial ischemia reperfusion injury in rats
Drug Design, Development and Therapy, 2014 Nan Wu, Wenna Li, Wenqi Shu, Dalin Jia Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China Abstract: The aim of this study was to determine the effect of picroside II on ...
Wu N, Li W, Shu W, Jia D
doaj
Improved genetically-encoded, FlincG-type fluorescent biosensors for neural cGMP imaging. [PDF]
, 2013 Genetically-encoded biosensors are powerful tools for understanding cellular signal transduction mechanisms. In aiming to investigate cGMP signaling in neurones using the EGFP-based fluorescent biosensor, FlincG (fluorescent indicator for cGMP), we ...
Allerston, CK +7 more
core
Silicon tetrachloride and phenol as N(α)-t-butoxycarbonyl group deprotecting agent in solid phase peptide synthesis [PDF]
, 1996 The combination of 1M silicon tetrachloride and 3M phenol serves as an efficient N(α)-t-butoxycarbonyl deblocking agent in solid phase peptide synthesis, the duration of the cleavage being 10 min.
Gangadhar, B.P. +2 more
core +1 more source