Results 121 to 130 of about 4,929,250 (404)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Modular synthesis of CF2-containing compounds with PhSO2CF2H reagent through difluoromethylene radical anion synthon strategy

open access: yesNature Communications
Difluoromethylene moiety has gained widespread applications in pharmaceuticals, agrochemicals, and materials owing to its augmented lipophilicity and being bioisosteric to ethereal oxygen.
Shuo Sun   +6 more
doaj   +1 more source

Harnessing flavonoids to control probiotic function: in situ application of a naringenin-responsive genetic circuit

open access: yesMicrobiology Spectrum
Efforts to improve probiotics’ capabilities through synthetic biology have recently increased. Using naturally occurring plant-based compounds, such as flavonoids, as inputs of genetic circuits introduced in probiotics is a promising strategy to enhance ...
Brenno Wendler Miranda   +4 more
doaj   +1 more source

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1 [PDF]

open access: bronze, 2013
Durga Nand Tripathi   +6 more
openalex   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Revitalizing reformatsky reagent for catalyst-free direct alkylation with unactivated alkyl halides

open access: yesNature Communications
Reformatsky reagents are commonly employed with activated electrophiles, such as aldehydes, ketones, or activated alkyl halides. However, their limited nucleophilicity remains a considerable challenge for direct reactions with unactivated alkyl halides ...
Lingpu Meng   +6 more
doaj   +1 more source

Facile preparation of Ag2S/KTa0.5Nb0.5O3 heterojunction for enhanced performance in catalytic nitrogen fixation via photocatalysis and piezo-photocatalysis

open access: diamond, 2022
Lu Chen   +9 more
openalex   +1 more source

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