Results 81 to 90 of about 1,263,890 (294)

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Microbial Heterogeneity Regulates C, N, and P Cycling Responses to Precipitation in Casuarina equisetifolia Forests

Plants
While many environmental variables (e.g., temperature) exhibit only moderate variation, precipitation is a primary driver of soil carbon–nitrogen–phosphorus cycling in forest ecosystems, with soil microorganisms mediating these processes.
Linzhi Zuo, Kaixiong Xing, Kai Wu, Ying Wang, Xiaoming Wang, Hang Zhang, Lei Li   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Microbial Nitrogen cycling in Nevada Geothermal Springs [PDF]

, 2008
Hot spring habitats above maximum photosynthetic temperature (73 ºC) are not well understood with respect to nitrogen (N) cycling. Few predictions have been made, and even fewer measurements of in situ activities have been reported.
Dodsworth, Jeremy A., Chaires, Mitchell G., Hedlund, Brian P.   +2 more
core   +2 more sources

Cluster of Dominant Species and Grazing Jointly Influence the Soil Nitrogen and Phosphorus Cycling in Alpine Grasslands

Microorganisms
This study systematically analyzes the multi-layered regulatory mechanisms of grazing on soil nitrogen and phosphorus cycling functions, based on the combined effects of different grazing strategies and plant community spatial patterns in alpine ...
Wei Xu, Na Li, Wenting Liu, Weidong Lv, Mengqi Li, Haiming Ji, Yuzhen Liu, Xiaoxia Yang, Quanmin Dong   +8 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Reforestation significantly enriches soil microbial carbon, nitrogen, and phosphorus cycling genes but simplifies their co-occurrence network

Reforestation serves as one of the most effective strategies for mitigating global warming, but a comprehensive understanding of its impact on soil microbial biogeochemical cycling functions remains lacking.
Che, R, Liu, D, Zhuang, W, Li, K, Zhang, S, Fan, Q, Tudi, M, Chen, D, Li, T, Wang, F, Zhang, Z   +10 more
core   +1 more source

Impact of MgO Additions on the Oxidation Resistance and Compression Behavior of Vanadium Alloys

Advanced Engineering Materials, EarlyView.
An increase in oxidation resistance at 600 °C is achieved for alloys containing more than 2.5 wt.% MgO. It has been established that, along with V2O5, MgO6V2, and Mg2O7V2 are formed, which are presumed to enhance oxidative stability. Furthermore, the possible transformation of Mg‐vanadates through reaction with CO2, which presumably occurs in this ...
Ievgen Solodkyi, Mathias Galetz, Georg Hasemann, Fabian Lanoy, Emma White, Manja Krüger   +5 more
wiley   +1 more source

Modelling effects of acid deposition and climate change on soil and run-off chemistry at Risdalsheia, Norway [PDF]

, 2001
Elevated carbon dioxide levels, caused by anthropogenic emissions of carbon dioxide to the atmosphere, and higher temperature may lead to increased plant growth and uptake to nitrogen, but increased temperature may lead to increased nitrogen ...
Mol-Dijkstra, J.P., Kros, H., Mol-Dijkstra, J. P.   +2 more
core