Results 51 to 60 of about 127,598 (336)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Evidence of Downregulation in Atmospheric Nitrogen-Fixation Associated with Native Hawaiian Sugarcane (Saccharum officinarum L.) Cultivars

Plants, 2023
The study of nitrogen fixation in sugarcane has a long history that has demonstrated high potential but with substantial variation in results. This 32-month study sought to assess the response of nitrogen fixation associated with sugarcane (Saccharum ...
Noa Lincoln, Reinier Paul Santiago, Derek Tatum, Angel R. Del Valle-Echevarria   +3 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

No nitrogen fixation in the Bay of Bengal? [PDF]

Biogeosciences, 2019
Abstract. The Bay of Bengal (BoB) has long stood as a biogeochemical enigma, with subsurface waters containing extremely low, but persistent, concentrations of oxygen in the nanomolar range which – for some, yet unconstrained, reason – are prevented from becoming anoxic.
C. R. Löscher, C. R. Löscher, W. Mohr, H. W. Bange, D. E. Canfield   +4 more
openaire   +6 more sources

Atrazine sensitivity varies among soybean cultivars

Agrosystems, Geosciences & Environment
Atrazine carryover from application to a monocot crop may adversely affect soybean (Glycine max (L.) Merr.) grown in rotation. Here, we tested the hypothesis that genotype selection could reduce atrazine carryover damage to soybean.
Shwetha S. Ramanathan, Travis W. Gannon, Wesley J. Everman, Anna M. Locke   +3 more
doaj   +1 more source

Full-Fat Soybean Meals as an Alternative Poultry Feed Ingredient—Feed Processing Methods and Utilization—Review and Perspective

Animals
On a global scale, the poultry industry expands its wings in terms of meat and egg production to the masses. However, this industry itself requires a sustainable and permanent supply of different inputs, one of which is poultry feed and nutrition ...
Ondulla T. Toomer, Edgar Orlando Oviedo-Rondón, Muhammad Ali, Michael Joseph, Thien Vu, Ben Fallen, Rouf Mian   +6 more
doaj   +1 more source

Active Nitrogen Fixation by Iron-Reducing Bacteria in Rice Paddy Soil and Its Further Enhancement by Iron Application

Applied Sciences, 2023
In rice paddy soil, biological nitrogen fixation is important for sustaining soil nitrogen fertility and rice growth. Anaeromyxobacter and Geobacteriaceae, iron-reducing bacteria belonging to Deltaproteobacteria, are newly discovered nitrogen-fixing ...
Zhengcheng Zhang, Yoko Masuda, Zhenxing Xu, Yutaka Shiratori, Hirotomo Ohba, Keishi Senoo   +5 more
doaj   +1 more source

Estimating the potential of ionizing radiation-induced radiolysis for microbial metabolism in terrestrial planets with rarefied atmospheres [PDF]

arXiv, 2022
Ionizing radiation is known to have a destructive impact on biology by causing damage to the DNA, cells, and production of Reactive Oxygen Species (ROS) among other things. While direct exposure to high radiation dose is indeed not favorable for biological activity, ionizing radiation can, and in some cases is known to produce a number of biologically ...
arxiv