Results 61 to 70 of about 2,577,255 (258)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

N-Graphene Nanowalls via Plasma Nitrogen Incorporation and Substitution: The Experimental Evidence

Nano-Micro Letters, 2020
Incorporating nitrogen (N) atom in graphene is considered a key technique for tuning its electrical properties. However, this is still a great challenge, and it is unclear how to build N-graphene with desired nitrogen configurations.
Neelakandan M. Santhosh, Gregor Filipič, Eva Kovacevic, Andrea Jagodar, Johannes Berndt, Thomas Strunskus, Hiroki Kondo, Masaru Hori, Elena Tatarova, Uroš Cvelbar   +9 more
doaj   +1 more source

Stable isotope probing: Technical considerations when resolving ¹⁵N-labeled RNA in gradients [PDF]

, 2010
RNA based stable isotope probing (SIP) facilitates the detection and identification of active members of microbial populations that are involved in the assimilation of an isotopically labeled compound.
Addison, Sarah Louise, Lloyd-Jones, Gareth, McDonald, Ian R.   +2 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

In field N transfer, build-up, and leaching in ryegrass-clover mixtures [PDF]

, 2008
Two field experiments investigating dynamics in grass-clover mixtures were conducted, using 15N- and 14C-labelling to trace carbon (C) and nitrogen (N) from grass (Lolium perenne L.) and clover (Trifolium repens L. and Trifolium pratense L.).
Eriksen, J, Høgh-Jensen, H, Jensen, E S, Rasmussen, J   +3 more
core  

Nitrogen Abundances in Damped Ly alpha Galaxies

, 1998
Nitrogen abundances have been derived in Damped Ly alpha (DLA) galaxies at Zabs = 2.309, 2.827 and 3.025 toward the QSOs 0100+1300, 1425+6039 and 0347-3819 respectively.
Edmunds M. G., Fontana A., Gail H., Giovanni Vladilo, Kilian-Montenbruck J., Kulkarni V. P., Le Brun V., Matteucci F., Miriam Centurion, Molaro P., Paolo Molaro, Piercarlo Bonifacio, Renzini A., Savaglio S., Sneden C., Vila-Costas M. B., Walker D. D., Woosley S. E.   +17 more
core   +2 more sources

Tracking nitrogen losses in a greenhouse crop rotation experiment in North China using the EU-Rotate_N simulation model [PDF]

, 2010
Vegetable production in China is associated with high inputs of nitrogen, posing a risk of losses to the environment. Organic matter mineralisation is a considerable source of nitrogen (N) which is hard to quantify.
Ad-hoc-Arbeitsgruppe Boden, Addiscott, Cabrera, Chen, Chunguang Jiang, Claas Nendel, Clive Rahn, Fox, Fox, Gollany, Greenwood, Guo, Guo, He, He, He, Houba, Ju, Ju, Kotsiras, Li, Nash, Nendel, Nendel, Qing Chen, Rahn, Ramos, Ruiying Guo, Shen, Willmott, Zhang, Zhou, Zhu   +32 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

How exogenous nitric oxide regulates nitrogen assimilation in wheat seedlings under different nitrogen sources and levels.

PLoS ONE, 2018
Nitrogen (N) is one of the most important nutrients for plants and nitric oxide (NO) as a signaling plant growth regulator involved in nitrogen assimilation.
Sadegh Balotf, Shahidul Islam, Gholamreza Kavoosi, Bahman Kholdebarin, Angela Juhasz, Wujun Ma   +5 more
doaj   +1 more source

STUDI EFISIENSI PEMANFAATAN NITROGEN EMPAT VARIETAS PADI SAWAH PADA TANAH INCEPTISOL.

Jurnal Agrotropika, 2020
The research was conducted in Green House of Agricultural Faculty Jenderal Soedirman University Karangwangkal Village, North Purwokerto Subdistrict, Banyumas Regency. The research was performed at December 2007 until April 2008. Experimental design used
A.H. Syaeful Anwar, H. Darjanto
doaj   +1 more source