Results 41 to 50 of about 303,046 (215)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Removal efficiency of nitrogen and phosphorus in mariculture effluent by an immobilized algae-bacteria system

Aquaculture Reports
To explore the removal efficiency of nitrogen and phosphorus in mariculture effluent, Oocystis borgei and Algoriphagus marincola were used to construct an immobilized algae-bacteria system embedded in calcium alginate.
Junze Wu, Tong Li, Junting Li, Yongzhi Chen, Shafira Citra Desrika Putri, Yuge Peng, Ning Zhang, Yulei Zhang   +7 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Engineering operational efficiency analysis of Anammox process for mature landfill leachate

Gongye shui chuli
The mature landfill leachate is a typical high ammonia nitrogen and low C/N wastewater, which is difficult to be treated for nitrogen removal. This study proposed a large-scale SBR-denitrification-Anammox treatment system for mature landfill leachate ...
GU Xiaoyang, WANG Xiaojun, CHEN Zhenguo
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Optimizing nitrogen removal in vertical-flow constructed wetland: Effect of glucose addition and aeration duration

Guan'gai paishui xuebao
【Objective】Constructed wetlands are an effective technique for removing various organic and inorganic pollutants from wastewater. This study investigates the impact of glucose addition and intermittent aeration duration on nitrogen removal efficiency in ...
WANG Mingkuan, TONG Juxiu, ZHANG Xia
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Deciphering the ammonia transformation mechanism of a novel marine multi-stress-tolerant yeast, Pichia kudriavzevii HJ2, as revealed by integrated omics analysis

Applied and Environmental Microbiology
Ammonia nitrogen posed a significant threat to aquatic animals in aquaculture environments, and the substantial potential of microorganisms in removing ammonia nitrogen had garnered considerable attention.
Kunmei Huang, Huashan Bai, Can Meng, Muhammad Kashif, Zhiling Wei, Zaihang Tang, Shu He, Shanguang Wu, Sheng He, Chengjian Jiang   +9 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Insight into the nitrogen accumulation in urban center river from functional genes and bacterial community.

PLoS ONE, 2020
Along with urbanization, the intensified nitrogen pollution in urban rivers and the form of black-odor rivers has become one of the biggest concerns. Better understanding of the nitrogen transformations and microbial mechanisms occurring within urban ...
Lei Yu, ShuLei Liu, LiJuan Jiang, XiaoLin Wang, Lin Xiao   +4 more
doaj   +1 more source