Results 51 to 60 of about 30,292 (210)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Alternative Splicing of Neuropeptide Prohormone and Receptor Genes Associated with Pain Sensitivity Was Detected with Zero-Inflated Models

Biomedicines, 2022
Migraine is often accompanied by exacerbated sensitivity to stimuli and pain associated with alternative splicing of genes in signaling pathways. Complementary analyses of alternative splicing of neuropeptide prohormone and receptor genes involved in ...
Bruce R. Southey, Sandra L. Rodriguez-Zas   +1 more
doaj   +1 more source

Evaluating associations of migraine‐related vertigo

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective We set out to examine detailed phenotypic data from our clinic for associations of vertigo in chronic migraine. Background Vertigo is a non‐canonical, common symptom of migraine. Little is known about its associations with other symptoms within the migraine phenotype.
Nazia Karsan, Nicolas Vandenbussche, Robyn Jenia‐Wilcha, Pubudu Amarasena, Pannathat Soontrapa, Karthik Nagaraj, Carlo Lastarria Perez, Peter J. Goadsby   +7 more
wiley   +1 more source

A Comparison the Hemodynamic Changes between Cutaneous and Intravenous Nitroglycerin in Patients with Known Ischemic Heart Disease under Phacoemulsification Surgery

Iranian South Medical Journal, 2016
Background: In order to provide better hemodynamic control in patients with known ischemic  heart disase in phacoemulsification surgery under general anesthesia.
Abdolrasool Anvaripour, Lila Kazemi Zanjani, Abdolreza Najafi Anaraki, Kamran Mirzaei   +3 more
doaj  

Catheter Ablation: Evolution and Efficiencies

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT The present review includes a discussion the goals and pitfalls of efficiency in the medical profession, a historical perspective on the evolution of catheter ablation in the field of electrophysiology (EP), and the data regarding the relationship between efficiency and outcomes in the EP lab. Focus on efficacy is critical to maximize resource
Aravind G. Kalluri, Bradley P. Knight
wiley   +1 more source

The Swedish CArdioPulmonary bioImage Study re‐examination: Rationale, design, methods, and management of incidental findings

Journal of Internal Medicine, EarlyView.
Abstract Objectives To describe the rationale, design and data collection procedures of the Swedish CArdioPulmonary bioImage Study (SCAPIS) re‐examination, which, in its further scope, aims to quantify and explain the development of atherosclerosis, pathological cardiovascular ageing, longitudinal decline in lung function and the malignant ...
Elin Good, Göran Bergström, Anders Blomberg, Viiu Blöndal, Gunnar Engström, Erika Fagman, Klas Gränsbo, Shabab Hasan, Shadi Jalali, Tomas Jernberg, Åse Johnsson, Ioannis Katsoularis, Jeanette Kuhl, Andrei Malinovschi, Lina Malm, Vibeke Sparring, Eva Swahn, Richard Ssegonja, Jelmer Westra, Mischa Woisetschläger, Carl Johan Östgren, Emil Hagström   +21 more
wiley   +1 more source

Initial UK Experience of Focal Pulsed Field Ablation

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background Pulsed field ablation (PFA) offers potential safety and efficacy advantages for catheter ablation. Delivering this energy source using pre‐existing contact force sensing catheters and mapping systems is attractive due to familiarity and accessibility.
Waqas Ullah, Daniel Raine, Maciej Debski, Shi Rui, Vasanth Sritharan, Wissam Ahmed, Arthur Yue, Tom Wong, Moloy Das   +8 more
wiley   +1 more source

Comparing the Effect of Nitroglycerine and Dexamethasone as Adjuvants in Intravenous Regional Anesthesia: A Randomized Clinical Trial

مجله دانشکده پزشکی اصفهان, 2018
Background: Previous studies evaluated the effects of adding nitroglycerin and dexamethasone to lidocaine on the quality of the intravenous regional anesthesia (IVRA).
Ebrahim Hassani, Alireza Mahoori, Mir-Mousa Aghdashi, Negin Hoseinzadeh, Asma Hassani   +4 more
doaj   +1 more source

Nitroglycerin Use in the Emergency Department: Current Perspectives

Open Access Emergency Medicine, 2022
Michael J Twiner,1,2 John Hennessy,3 Rachel Wein,1 Phillip D Levy1,2 1Department of Emergency Medicine, Wayne State University, Detroit, MI, USA; 2Integrative Biosciences Center, Wayne State University, Detroit, MI, USA; 3College of Engineering ...
Twiner MJ, Hennessy J, Wein R, Levy PD
doaj  

Establishment of a mouse model for ischaemic heart failure induced by coronary microembolization via left ventricular oil injection

Experimental Physiology, EarlyView.
Abstract Over the past three decades, there has been a steady increase in clinical attention to ischaemic heart failure caused by coronary microembolization. Nonetheless, a suitable mouse model for studying this condition remains limited. In the present study, we developed a mouse model of coronary microembolization‐induced ischaemic heart failure by ...
Lang Pei, Yusheng Hong, Qiuyue Wu, Jianyi Lv, Changlong Li, Xueyun Huo, Xin Liu, Di Zhang, Meng Guo, Zhenwen Chen, Xiaoyan Du   +10 more
wiley   +1 more source