Results 71 to 80 of about 50,970 (263)

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Potentiation of the hemodynamic effects of acutely administered nitroglycerin by methionine.

, 1988
It is believed that nitroglycerin causes vasodilatation by interacting with sulfhydryl groups present in vascular smooth muscle. This study was performed to assess whether methionine, an amino acid capable of increasing sulfhydryl availability, would ...
Levy, W. S., W S Levy, R J Katz, Katz, R. J., Leiboff, R. H., R L Ruffalo, R H Leiboff, A G Wasserman, Ruffalo, R. L., Wasserman, A. G.   +9 more
core   +1 more source

Continuous transdermal nitroglycerin therapy for menopausal hot flashes [PDF]

, 2016
OBJECTIVE: To describe the efficacy and tolerability of continuous nitroglycerin for treatment of hot flashes. METHODS: Perimenopausal and postmenopausal women reporting at least seven hot flashes per day were recruited into a single-arm, dose-escalation
Schembri, Michael, Vittinghoff, Eric, Grady, Deborah, Cummings, Steven R, Huang, Alison J, Ganz, Peter   +5 more
core   +1 more source

GLP‐1 receptor activation attenuates chronic migraine‐like behaviour: Sex‐specific modulation of opioid‐ and endocannabinoid‐related pathways

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic migraine (CM) is a highly disabling condition that remains suboptimally treated. Metabolic disturbances may trigger migraine chronification, whereas impaired endogenous pain inhibition contributes to CM development. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), used for type 2 diabetes and obesity, show efficacy ...
Katarina Sićović, Katarina Nastić, Miroslav Dinić, Emilija Brdarić, Uroš Pecikoza, Maja Tomić, Ana Micov   +6 more
wiley   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

A Comparison the Hemodynamic Changes between Cutaneous and Intravenous Nitroglycerin in Patients with Known Ischemic Heart Disease under Phacoemulsification Surgery

Iranian South Medical Journal, 2016
Background: In order to provide better hemodynamic control in patients with known ischemic  heart disase in phacoemulsification surgery under general anesthesia.
Abdolrasool Anvaripour, Lila Kazemi Zanjani, Abdolreza Najafi Anaraki, Kamran Mirzaei   +3 more
doaj  

Catheter Ablation: Evolution and Efficiencies

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT The present review includes a discussion the goals and pitfalls of efficiency in the medical profession, a historical perspective on the evolution of catheter ablation in the field of electrophysiology (EP), and the data regarding the relationship between efficiency and outcomes in the EP lab. Focus on efficacy is critical to maximize resource
Aravind G. Kalluri, Bradley P. Knight
wiley   +1 more source

Intravenous nitroglycerin-induced heparin resistance: a qualitative antithrombin III abnormality

, 2008
An ability of intravenous nitroglycerin to interfere with the anticoagulant properties of intravenous heparin would have profound clinical implications.
Bovill, Edwin G., Miller, Michael L., Becker, Richard C., Corrao, Jeanne M., Gore, Joel M., Lucas, Fred V., Baker, Stephen P., Alpert, Joseph S.   +7 more
core   +1 more source

A Comparison of Labetalol and Nitroglycerin for The Management of Intraoperative Hypertension in Ambulatory Surgical Patients Who Underwent Cataract Surgery

Archives of Anesthesia and Critical Care, 2018
Background: This is a prospective randomized blinded clinical trial comparing the efficacy and safety of labetalol and nitroglycerin for the management of intraoperative hypertension in ambulatory surgical patients who underwent cataract surgery. Methods:
Mehdi Sanatkar, Hossein Sadrossadat, Mehrdad Goudarzi, Ebrahim Espahbodi, Masoumeh Zangeneh   +4 more
doaj   +1 more source